Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine
D-pofol
Preducted Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction
1 other identifier
interventional
40
0 countries
N/A
Brief Summary
Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump. Effect site concentraion of propofol start from 5 and changes the concentration as previous response to i-gel insertion as up and down methods
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Oct 2014
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2014
CompletedFirst Submitted
Initial submission to the registry
October 9, 2014
CompletedFirst Posted
Study publicly available on registry
October 20, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2015
CompletedResults Posted
Study results publicly available
August 3, 2022
CompletedAugust 3, 2022
August 1, 2022
4 months
October 9, 2014
February 14, 2019
August 1, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Concentration of Propofol
effect site concentration of propofol
from i-gel insertion up to 5 min
Study Arms (2)
concentration of propofol in male
OTHERafter infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in male
concentration of propofol in female
OTHERafter infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in female
Interventions
First subjects start from effect site concentraion of 5ug/ml propofol, after insertion of i-gel, determine the next subjects' effect site concentraion would be increae or decrease 0.5 ug/ml as up and down method
Eligibility Criteria
You may qualify if:
- ASA PS I-II, 20-60 yrs old
You may not qualify if:
- predicted difficulty airway, recent URI, BMI \> 30kg/m2, reactive airway disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Choi JJ, Kim JY, Lee D, Chang YJ, Cho NR, Kwak HJ. Male patients require higher optimal effect-site concentrations of propofol during i-gel insertion with dexmedetomidine 0.5 mug/kg. BMC Anesthesiol. 2016 Mar 22;16:20. doi: 10.1186/s12871-016-0186-1.
PMID: 27004426DERIVED
MeSH Terms
Conditions
Results Point of Contact
- Title
- Dr. Hyun Jeong Kwak
- Organization
- Gil hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant professor
Study Record Dates
First Submitted
October 9, 2014
First Posted
October 20, 2014
Study Start
October 1, 2014
Primary Completion
February 1, 2015
Study Completion
February 1, 2015
Last Updated
August 3, 2022
Results First Posted
August 3, 2022
Record last verified: 2022-08