Supraspinal Contributions to the Control of Human Locomotion: Clinical and Fundamental Aspects

NCT02263560 | Completed

• 1 other identifier: UFribourg
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Many neurological patients express enhanced deficits while walking in a dark room (or during the night): the supraspinal structures involved in this navigational deficit have not been identified yet. In this project, the investigators will study post-stroke gaits of human patients and compare them to those of a control population during a goal-oriented task performed in different visual conditions. The investigators want to test the hypothesis that during simple goal-oriented locomotor tasks, only patients with specific (e.g. medio or infero- temporal) lesions will express navigational deficits.

Conditions

Post-stroke Gait Assessments

Outcome Measures

Primary Outcomes (2)

• Walking stability indices of post-stroke patients

  1 hour and 30 minutes (including pre-tests, instructions delivery...).

• Spatial accuracy of walking trajectories in post-stroke patients

  1 hour and 30 minutes (including pre-tests, instructions delivery...).

Study Arms (2)

Post-stroke patients

Patients who experienced stroke and who already recover gait abilities.

Behavioral: Kinematic measurements

Control population

Participants matching the criterion (age and gender) of the patients' group.

Behavioral: Kinematic measurements

Interventions

Kinematic measurements BEHAVIORAL

Control population; Post-stroke patients

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The selected patients will be described by following parameters: * Parameters in relation to the person: age, gender. * Parameters in relation to the pathology: NIHSS, exact localisation, time since start of the symptoms, FIM (functional independence measure) visual field (ophthalmological examen), visual acuity (ophtalmological examen), visual neglect (Bells Cancellation Task), visuo-spatial short term working memory (Corsi span), visual motor integration (3-D cub subtest MoCA) * Parameters in relation to hospital stay: length of stay.

You may qualify if:

• Adult male and female subjects (18--\>85 years old)

You may not qualify if:

• Persons with history of an acquired or congenital neurological disorder, e.g. stroke, multiple sclerosis, Parkinson disease, increased intracranial pressure, etc.;
• Persons injured at the time of the experiments (fractures,…);
• Persons having reported repetitive spatial troubles/disorders;
• Persons with eye disorders and non-corrected vision problems;
• Pregnant women.

Sponsors & Collaborators

• University of Fribourg: lead
• Dr Titus Bihl, Hopital Cantonal Fribourgeois: collaborator

Study Sites (1)

University (UNIFR) and Hospital of Fribourg (HFR)

Fribourg, 1700, Switzerland

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer (PhD)

Study Record Dates

• First Submitted: October 6, 2014
• First Posted: October 13, 2014
• Study Start: March 1, 2014
• Primary Completion: January 1, 2015
• Study Completion: March 1, 2016
• Last Updated: October 25, 2017

Record last verified: 2017-10

Locations

CH (1)