Lung Function Decline and Disease Risk From Young Adulthood to Middle Age

NCT02245178 | Completed DMC

• 2 other identifiers: STU00090966R01HL122477
• Study Type: observational
• Target: 3,193
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified. Individuals with lung disease frequently have concurrent cardiovascular disease, but the reason for this is not well understood. In this study, we will identify markers that predict risk of future lung disease and evaluate the concurrent subclinical evolution of lung and heart dysfunction. This will allow for targeting of preventive strategies to stop the rising incidence of COPD and other lung diseases and provide insights into why heart and lung disease frequently occur together.

Conditions

COPD; Lung Function; Heart - Lung Interaction; Restrictive Lung Disease

Outcome Measures

Primary Outcomes (1)

• Incident COPD

  From cohort initiation, predictors of incident COPD

  30 years

Secondary Outcomes (1)

• Incident restriction

  30 years

Study Arms (1)

Obervational - CARDIA participants

CARDIA study participants will undergo lung function testing and have existing thoracic CT scans analyzed for lung structure.

Procedure: Lung spirometry; Other: CT scan analysis

Interventions

Lung spirometry PROCEDURE

measurement of pulmonary function pre- and post-bronchodilator

Also known as: lung function

Obervational - CARDIA participants

CT scan analysis OTHER

Analysis of existing year 25 thoracic CT scans for lung and intrathoracic vascular structure

Obervational - CARDIA participants

Eligibility Criteria

• Age: 48 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants in the main Coronary Artery Risk Development in Young Adults (CARDIA) cohort study attending the year 30 examination

You may qualify if:

• Participation in the main CARDIA examination at year 30

You may not qualify if:

• Shortness of breath with pain in the chest within the past week
• Heart attack or stroke within the past month

Sponsors & Collaborators

• Northwestern University: lead
• University of Minnesota: collaborator
• University of Alabama at Birmingham: collaborator
• University of Kentucky: collaborator
• Kaiser Foundation Research Institute: collaborator
• Brigham and Women's Hospital: collaborator
• Vanderbilt University: collaborator
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Ventilation

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Environment, Controlled; Environment; Environment and Public Health

Study Officials

• Ravi Kalhan, MD

  Northwestern University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 17, 2014
• First Posted: September 19, 2014
• Study Start: June 1, 2015
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2018
• Last Updated: August 22, 2018

Record last verified: 2018-08