NCT02242513

Brief Summary

Although there are many conservative method for plantar fasciitis, patients might spend 2 years to achieve resolution. Recent study have shown that pulsed radiofrequency (PRF) lesioning of peripheral nerve can alleviate kinds of pain condition. However there are no studies of PRF lesioning of the tibial nerve in patients with plantar fascilitis by using ultrasound-guided (UG) techniques.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2014

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2014

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 10, 2014

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 17, 2014

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2016

Completed
Last Updated

December 1, 2016

Status Verified

November 1, 2016

Enrollment Period

2.3 years

First QC Date

September 10, 2014

Last Update Submit

November 30, 2016

Conditions

Keywords

Pulsed mode radiofrequencyPlantar FasciitisUltrasound-guided

Outcome Measures

Primary Outcomes (1)

  • Change from baseline of pain on 4th, 8th and 12th weeks after treatment.

    Using the Visual analog scale (VAS) and subscore of foot health status questionnaire to measure the pain scale before treatment and multiple time frame after treatment.

    Baseline , 4th, 8th and 12th weeks after treatment.

Secondary Outcomes (2)

  • Change from baseline of functional improvement on 4th, 8th and 12th after treatment.

    Baseline , 4th, 8th and 12th weeks after treatment.

  • Change from baseline of thickness of plantar fascile on 4th, 8th and 12th weeks after treatment.

    Baseline , 4th, 8th and 12th weeks after treatment.

Study Arms (2)

pulsed mode radiofrequency

ACTIVE COMPARATOR

Pulsed radiofrequency (PRF) treatment, a relative novel pain intervention at recent decade, was found to be able to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue in the absence of neural injury. One dose of PRF was given in tibial nerve behine the medial ankle in intervention group.

Device: Pulsed radiofrequency (PRF)

Xylocaine

PLACEBO COMPARATOR

2 c.c xylocaine was given in tibial nerve behind the medial ankle in control group.

Drug: Xylocaine

Interventions

Pulsed radiofrequency (PRF) treatment, a relative novel pain intervention at recent decade, was found to be able to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue in the absence of neural injury.

Also known as: Neurotherm NT1000, Neurotherm Inc., USA
pulsed mode radiofrequency
Xylocaine

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Heel pain more than 3 months
  • Age more than 20 year-old
  • The increased thickness of plantar fascile (\>4mm) measured by sonography
  • Must be conscious
  • Not receive steroid or other injection in plantar fascile in past 6 months

You may not qualify if:

  • Cancer of any site
  • Coagulopathy
  • Pregnancy
  • Inflammation status

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tri-Service General Hospital, School of Medicine, National Defense Medical Center

Taipei, Neihu District, 886, Taiwan

Location

Related Publications (6)

  • Martin DC, Willis ML, Mullinax LA, Clarke NL, Homburger JA, Berger IH. Pulsed radiofrequency application in the treatment of chronic pain. Pain Pract. 2007 Mar;7(1):31-5. doi: 10.1111/j.1533-2500.2007.00107.x.

    PMID: 17305676BACKGROUND
  • Van Zundert J, Patijn J, Kessels A, Lame I, van Suijlekom H, van Kleef M. Pulsed radiofrequency adjacent to the cervical dorsal root ganglion in chronic cervical radicular pain: a double blind sham controlled randomized clinical trial. Pain. 2007 Jan;127(1-2):173-82. doi: 10.1016/j.pain.2006.09.002. Epub 2006 Oct 18.

    PMID: 17055165BACKGROUND
  • Rohof OJ. Radiofrequency treatment of peripheral nerves. Pain Pract. 2002 Sep;2(3):257-60. doi: 10.1046/j.1533-2500.2002.02033.x.

    PMID: 17147740BACKGROUND
  • Thapa D, Ahuja V. Combination of diagnostic medial calcaneal nerve block followed by pulsed radiofrequency for plantar fascitis pain: A new modality. Indian J Anaesth. 2014 Mar;58(2):183-5. doi: 10.4103/0019-5049.130824.

  • Erken HY, Ayanoglu S, Akmaz I, Erler K, Kiral A. Prospective study of percutaneous radiofrequency nerve ablation for chronic plantar fasciitis. Foot Ankle Int. 2014 Feb;35(2):95-103. doi: 10.1177/1071100713509803. Epub 2013 Oct 28.

  • Sean NY, Singh I, Wai CK. Radiofrequency microtenotomy for the treatment of plantar fasciitis shows good early results. Foot Ankle Surg. 2010 Dec;16(4):174-7. doi: 10.1016/j.fas.2009.10.008. Epub 2009 Nov 25.

MeSH Terms

Conditions

Fasciitis, Plantar

Interventions

Pulsed Radiofrequency TreatmentLidocaine

Condition Hierarchy (Ancestors)

FasciitisMusculoskeletal DiseasesFoot Diseases

Intervention Hierarchy (Ancestors)

Electric Stimulation TherapyTherapeuticsPhysical Therapy ModalitiesRadiofrequency TherapyRehabilitationAcetanilidesAnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Study Officials

  • Liang-Cheng Chen, MD, MS

    Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, National Defense Medical Center,

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Attending Physician

Study Record Dates

First Submitted

September 10, 2014

First Posted

September 17, 2014

Study Start

April 1, 2014

Primary Completion

July 1, 2016

Study Completion

July 1, 2016

Last Updated

December 1, 2016

Record last verified: 2016-11

Locations