NCT02240069

Brief Summary

A critical need exists for efficient community-based interventions aimed at reduction of environmental exposures relevant to health. Biomass smoke exposures due to residential wood heating are common among rural Native American communities, and such exposures have been associated with respiratory disease in susceptible populations. In many of these communities wood stoves are the most economic and traditionally preferred method of residential heating, but resource scarcity can result in burning of improper wood fuels and corresponding high levels of indoor particulate matter. Community-based participatory research techniques will be used to adapt intervention approaches to meet the cultural context of each participating community. At the community level, investigators will facilitate local development of a tribal agency-led wood bank program ensuring that elderly and/or persons with need have access to dry wood for heating. At the household level, investigators will use a three arm randomized placebo-controlled intervention trial to implement and assess education/outreach on best burn practices (Tx1). The content and delivery strategies of the education intervention will be adapted to each community according to stakeholder input. This educational intervention will be evaluated against an indoor air filtration unit arm (Tx2), as well as a placebo arm (Tx3, sham air filters). Tx3 will be used in comparison with the other two treatment arms to evaluate the penetration and efficacy of the community-level wood bank program. Outcomes will be evaluated with respect to changes in pulmonary function measures and respiratory symptoms and conditions among household elders. The investigators hypothesize that locally-designed education-based interventions at the community and household levels will result in efficacious and sustainable strategies for reducing personal exposures to indoor particulate matter, and lead to respiratory health improvements in elderly Native populations. This study will advance knowledge of cost-effective environmental interventions within two unique Native American communities, and inform sustainable multi-level strategies in similar communities throughout the US to improve respiratory health among at-risk populations.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
149

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2015

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 10, 2014

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 15, 2014

Completed
1.2 years until next milestone

Study Start

First participant enrolled

November 30, 2015

Completed
4.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2020

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2021

Completed
1.8 years until next milestone

Results Posted

Study results publicly available

December 1, 2022

Completed
Last Updated

December 1, 2022

Status Verified

November 1, 2022

Enrollment Period

4.6 years

First QC Date

September 10, 2014

Results QC Date

November 2, 2022

Last Update Submit

November 2, 2022

Conditions

Outcome Measures

Primary Outcomes (5)

  • Post-intervention FEV1

    Mean of up to two post-intervention measures of forced expiratory volume at one second (FEV1), liters

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Health measures were collected at two visits during both winter periods with each visit separated by at least three weeks.

  • Post-intervention FVC

    Mean of up to two post-intervention measures of forced vital capacity (FVC), liters

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Health measures were collected at two visits during both winter periods with each visit separated by at least three weeks.

  • Post-intervention FEV1/FVC Ratio

    Mean of up to two post-intervention measures of forced expiratory volume at one second (FEV1) / forced vital capacity (FVC)

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Health measures were collected at two visits during both winter periods with each visit separated by at least three weeks.

  • Post-intervention Systolic Blood Pressure

    Mean of up to two post-intervention measures of systolic blood pressure, millimeters of mercury (mmHg)

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Health measures were collected at two visits during both winter periods with each visit separated by at least three weeks.

  • Post-intervention Diastolic Blood Pressure

    Mean of up to two post-intervention measures of diastolic blood pressure, millimeters of mercury (mmHg)

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Health measures were collected at two visits during both winter periods with each visit separated by at least three weeks.

Secondary Outcomes (1)

  • Post-intervention Indoor Fine Particulate Matter (PM2.5)

    Each participant was followed during a pre-intervention baseline (Winter 1) and a post-intervention follow-up period (Winter 2). Indoor 48-hour PM2.5 average concentration was measured at two post-intervention visits separated by at least three weeks.

Study Arms (3)

Education (Tx1)

EXPERIMENTAL

Education on best burn practices

Behavioral: Education (Tx1)

Air Filtration Unit Treatment (Tx2)

ACTIVE COMPARATOR

A 20" x 18" Filtrete air filtration unit (3M, St. Paul, MN) will be placed in the same room as the wood stove.

Device: Air Filtration Unit Treatment (Tx2)

Placebo Intervention (Tx3)

SHAM COMPARATOR

A 20" x 18" Filtrete air filtration unit will be installed within the wood stove home. Instead of a high efficiency filter, the units will utilize a placebo filter.

Device: Placebo Intervention (Tx3)

Interventions

Education (Tx1)BEHAVIORAL

Education on best burn practices

Education (Tx1)

A 20" x 18" Filtrete air filtration unit (3M, St. Paul, MN) will be placed in the same room as the wood stove

Air Filtration Unit Treatment (Tx2)

A 20" x 18" Filtrete air filtration unit will be installed within the wood stove home. Instead of a high efficiency filter, the units will utilize a placebo filter.

Placebo Intervention (Tx3)

Eligibility Criteria

Age55 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Tribal member from one of the two study regions
  • Age 55 years or older.
  • Utilize a wood stove as the primary heating source.
  • Capable and willing to record symptom data and wood stove usage data, as well as complete pulmonary function testing (i.e., spirometry).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Montana

Missoula, Montana, 59812, United States

Location

MeSH Terms

Interventions

Educational Status

Intervention Hierarchy (Ancestors)

Socioeconomic FactorsPopulation Characteristics

Results Point of Contact

Title
Curtis Noonan
Organization
University of Montana

Study Officials

  • Curtis W Noonan, Ph.D.

    University of Montana

    PRINCIPAL INVESTIGATOR
  • Annie Belcourt, Ph.D.

    University of Montana

    PRINCIPAL INVESTIGATOR
  • Tony J Ward, Ph.D.

    University of Montana

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator, Professor

Study Record Dates

First Submitted

September 10, 2014

First Posted

September 15, 2014

Study Start

November 30, 2015

Primary Completion

June 30, 2020

Study Completion

February 28, 2021

Last Updated

December 1, 2022

Results First Posted

December 1, 2022

Record last verified: 2022-11

Locations