Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery

NCT02233010 | Completed

• 1 other identifier: postOPNGAL01
• Study Type: observational
• Target: 43
• Locations: 0 countries
• Sites: N/A

Brief Summary

Although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of renal function. Neutrophil Gelatinase-associated Lipocalin (NGAL's) usefulness as an evidence for acute kidney damage occurring from post-op cardiac surgery, being critical patients and contrast medium use is already proven. But NGAL's usefulness for renal function after non-cardiac surgery is not proven and especially, NGAL's usefulness for renal injury after non-cardiac surgery in chronic renal disease patients is not proven.Therefore, the investigators will study about renal function decrease after non-cardiac surgery with NGAL and serum creatinine.

Conditions

Chronic Kidney Disease

Outcome Measures

Primary Outcomes (1)

• serum NGAL level

  up to post operation 12 hours

Study Arms (2)

kidney function normal group

kidney function normal group : defined by the normal level of NGAL after post operation 4hrs

Other: The level of NGAL after pre op,post op 4hr, post op 12hr

kidney function decreased group

kidney function decreased group : defined by the increased level of NGAL after post operation 4hrs

Other: The level of NGAL after pre op,post op 4hr, post op 12hr

Interventions

The level of NGAL after pre op,post op 4hr, post op 12hr OTHER

kidney function decreased group; kidney function normal group

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

43 patients who had non-cardiac surgery in Seoul Paik Hospital.

You may qualify if:

• patients who had non-cardiac surgery in Seoul Paik Hospital.

You may not qualify if:

• have viral hepatitis and Aspartate aminotransferase, Alanine aminotransferase \> 2 time of normal level
• severe lung disease
• severe heart failure ( Ejection Fraction \< 40% )
• pregnancy

Sponsors & Collaborators

• Inje University: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Hoseok Koo

Study Record Dates

• First Submitted: September 1, 2014
• First Posted: September 8, 2014
• Study Start: February 1, 2014
• Primary Completion: August 1, 2014
• Last Updated: September 8, 2014

Record last verified: 2014-09