Absorption of Mango in Healthy Individuals
Profile of Metabolites After the Intake of Mango (Mangifera Indica, l.) Var. Keitt in Humans
1 other identifier
interventional
30
1 country
1
Brief Summary
The objective of this research is to characterize the urinary metabolites produced after the consumption of mango pulp in an effort to begin to characterize the bioavailability of the major group of polyphenolics in mango, ester-linked gallic acids, and to provide new insight into their in vivo physiological behavior.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 4, 2014
CompletedFirst Posted
Study publicly available on registry
August 28, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2017
CompletedOctober 18, 2016
October 1, 2016
3.8 years
June 4, 2014
October 14, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Change from baseline in the levels of metabolites of gallic acid in urine after mango intake.
Aliquoted urine samples were thawed and centrifuged at 13,000 x g for 10 mins at 4°C immediately prior to analysis by HPLC-MSn. All quantification of metabolites (pyrogalloyl-O-glucuronide, O-methyl-gallic acid, O-methylgallic acid-O-sulfate, O-methylpyrogalloyl-O-sulfate, pyrogalloyl-O-sulfate, deoxypyrogallol-O-sulfate, O-methylpyrogalloyl-O-sulfate) was performed in full MS and expressed as gallic acid equivalents. To standardize the concentration of metabolites for the sake of comparison across varying weights, heights, and volume of urine collected by each participant; urinary creatinine concentrations were calculated for each sample using a routine Creatinine enzyme assay kit (Sigma-Aldrich). All values are expressed as mg of standard/10 mg creatinine (mg gallic acid equivalent /10mg creatinine).
1 year
Study Arms (2)
Sugary beverage
PLACEBO COMPARATORSugary beverage
Mango beverage
EXPERIMENTALMango polyphenolics
Interventions
15.7g sugar, 3.8g pectin and 0.05g citric acid was added in 100ml of the control beverage.
Eligibility Criteria
You may qualify if:
- No medical history of digestive disorders or chronic diseases
You may not qualify if:
- Have medical history of digestive disorders or chronic diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Exercise & Sport Nutrition Laboratory (ESNL) in the Department of Health and Kinesiology at Texas A&M University
College Station, Texas, 77845, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Susanne Talcott, Ph.D.
Texas A&M University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 4, 2014
First Posted
August 28, 2014
Study Start
March 1, 2013
Primary Completion
December 1, 2016
Study Completion
December 1, 2017
Last Updated
October 18, 2016
Record last verified: 2016-10