Hemodialysis and Wanting for Protein-rich Foods

NCT02221050 | Completed

• 1 other identifier: 2013/28
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

A study conducted in the laboratory revealed the existence of a "window" during which patients with renal failure appreciate the protein-rich foods. This period, located immediately after the dialysis, is likely related to the purification of plasma products resulting from protein catabolism. It therefore appears necessary to understand the mechanisms that may explain these changes by measurements of ghrelin (orexigenic hormone), leptin (anorectic hormone) and plasma amino acids.

Conditions

Renal Failure

Outcome Measures

Primary Outcomes (1)

• Amount of wanting for protein-rich foods

  The wanting is determined after the successive presentation (for ten seconds) of 18 pictures of food. For each food the question is "at the present time, do you want to eat this food? ". For each photo, subjects place a vertical line on a 10 cm horizontal line bounded at its ends by "no desire" and "extremely envy" (visual analog scale).The wanting for proteins is the mean score for the desire to eat protein-rich foods.

  20 min (from 8:00 to 8:20 am) and 20 min (from 11:00 to 11:20 am)

Secondary Outcomes (1)

• Concentrations of the plasma amino-acids

  8:30 am and 11:30 am

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

hemodialysis centers of Clinique Drevon, Dijon, France la Breuchillière, Saint Apollinaire, France University Hospital, Dijon, France Macon Hospital, Macon, France

You may qualify if:

• Patients and healthy subjects were included if they were aged between 18 and 80 years

You may not qualify if:

• diabetes, advanced undernutrition (BMI \< 17.5 kg m-2, prealbumin \< 250 mg.L-1), congestive heart failure, acute or chronic infection, ongoing antibiotic treatment, active cancer, liver cirrhosis, smoking (more than 5 cigarettes/day), alcohol consumption (more than 3 units/day), aversion to the foods eaten or smelt during the study, impaired comprehension of the cognitive tasks

Sponsors & Collaborators

• University of Burgundy: lead

Study Sites (1)

Centre des Sciences du Goût

Dijon, Burgundy, 21000, France

Location

Related Publications (1)

• Mouillot T, Filancia A, Boirie Y, Brindisi MC, Hafnaoui N, Van Wymelbeke V, Teillet E, Meintani I, Jacquin-Piques A, Leloup C, Penicaud L, Mousson C, Brondel L. Hemodialysis Affects Wanting and Spontaneous Intake of Protein-Rich Foods in Chronic Kidney Disease Patients. J Ren Nutr. 2021 Mar;31(2):164-176. doi: 10.1053/j.jrn.2020.05.006. Epub 2020 Jul 25.

  PMID: 32723525 DERIVED

MeSH Terms

Conditions

Renal Insufficiency

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Luc PENICAUD, PHD

  Centre des Sciences du Goût, Centre National de la recherche Scientifique

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 15 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: University professor

Study Record Dates

• First Submitted: August 13, 2014
• First Posted: August 20, 2014
• Study Start: January 1, 2014
• Primary Completion: May 1, 2014
• Study Completion: July 1, 2014
• Last Updated: August 20, 2014

Record last verified: 2014-08

Locations

FR (1)