Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40 in Vitrectomy

NCT02212340 | Completed

• 1 other identifier: 3-2014-0104
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia. However, there have not been studies comparing the quality of recovery from the different methods of general anesthesia in vitrectomy. In this study, the investigators compare the functional recovery after general anesthesia in TIVA and inhalation anesthesia with QoR-40 questionnaire in vitrectomy.

Conditions

Vitrectomy Operation Under General Anesthesia

Keywords

propofol; desflurane; quality of recovery; vitrectomy

Outcome Measures

Primary Outcomes (1)

• QoR-40 score

  at 6 hours later after surgery

Study Arms (2)

TIVA group

EXPERIMENTAL

Anesthesia is maintained with fresofol and remifentanil

Drug: fresofol and remifentanil

Des group

ACTIVE COMPARATOR

Anesthesia is maintained with desflurane and remifentanil

Drug: desflurane and remifentanil

Interventions

fresofol and remifentanil DRUG

Anesthesia is maintained with fresofol and remifentanil in TIVA group or with desflurane and remifentanil in Des group according to randomly allocated group.

TIVA group

desflurane and remifentanil DRUG

Anesthesia is maintained with fresofol and remifentanil in TIVA group or with desflurane and remifentanil in Des group according to randomly allocated group.

Des group

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients (20-80 years old) scheduled for vitrectomy surgery undergoing general anesthesia.
• ASA 1-3

You may not qualify if:

• Patients with allergy to anesthetic agents
• Anticipated difficult airway
• BMI \> 30 kg/m2
• Chronic obstructive pulmonary disease
• Heart failure 6. Unstable angina

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Gangnam Severance Hospital, Yonsei University College of Medicine

Seoul, Seoul, 120-752, South Korea

Location

MeSH Terms

Interventions

Propofol; Remifentanil; Desflurane

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Propionates; Acids, Acyclic; Carboxylic Acids; Piperidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Ethyl Ethers; Ethers; Methyl Ethers; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 6, 2014
• First Posted: August 8, 2014
• Study Start: July 1, 2014
• Primary Completion: January 1, 2016
• Study Completion: March 1, 2016
• Last Updated: September 27, 2016

Record last verified: 2016-09

Locations

KR (1)