NCT02201121

Brief Summary

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
94

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2014

Shorter than P25 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2014

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2014

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

July 22, 2014

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 25, 2014

Completed
Last Updated

July 25, 2014

Status Verified

October 1, 2013

Enrollment Period

3 months

First QC Date

July 22, 2014

Last Update Submit

July 24, 2014

Conditions

CirculationDrug DoseCalculated SAP

Outcome Measures

Primary Outcomes (1)

  • invasive arterial blood pressure as a Measure of Safety

    if instability of circulation, stop the clinical trial

    DAY 1

Study Arms (1)

phenylephrine group, dopamine group, ephedrine group

EXPERIMENTAL

phenylephrine group: use the phenylephrine to increase the SAP from low to high level. dopamine group: use the dopamine to increase the SAP from low to high level. ephedrine group:use the ephedrine to increase the SAP from low to high level.

Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation

Interventions

Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variationOTHER

This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure

phenylephrine group, dopamine group, ephedrine group

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Their American Society of Anesthesiologists (ASA) physical status was 1 or 2
  • Body mass index (BMI) ranged from 18 to 26
  • None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance
  • All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection

You may not qualify if:

  • Persistent arrhythmias
  • Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Dopamine

Intervention Hierarchy (Ancestors)

Biogenic MonoaminesBiogenic AminesAminesOrganic ChemicalsCatecholaminesCatecholsPhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbons

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
SINGLE
Who Masked
PARTICIPANT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Department of Anesthesiology, People's Liberation Army General Hospital, Beijing, China

Study Record Dates

First Submitted

July 22, 2014

First Posted

July 25, 2014

Study Start

March 1, 2014

Primary Completion

June 1, 2014

Study Completion

June 1, 2014

Last Updated

July 25, 2014

Record last verified: 2013-10