The Influence of Preoperative Warfarin Medication on Thromboelastography and Blood Transfusion
Influence of Warfarin on Thromboelastography and Transfusion
1 other identifier
observational
107
1 country
1
Brief Summary
Warfarin therapy is usually monitored using the international normalized ratio (INR), and prolonged INR means coagulation impairment that can leads elevating transfusion requirement after operation. This study was designed to assess the relationships with warfarin and TEG values related to transfusion amount, to set up blood transfusion strategy in patients on atrial fibrillation undergoing cardiac surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2014
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedFirst Submitted
Initial submission to the registry
June 29, 2014
CompletedFirst Posted
Study publicly available on registry
July 16, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2015
CompletedFebruary 25, 2015
February 1, 2015
8 months
June 29, 2014
February 23, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Rotational Thromboelastography : Clotting time (CT)
30min after anesthetic induction and 15 mins after CPB weaning status
Secondary Outcomes (1)
Rotational Thromboelastography : clot formation time (CFT)
30min after anesthetic induction and 15 mins after CPB weaning status
Other Outcomes (5)
Rotational Thromboelastography : maximum clot firmness (MCF)
30min after anesthetic induction and 15 mins after CPB weaning status
Rotational Thromboelastography : maximum lysis (ML) level Rotational Thromboelastography : maximum lysis (ML) level
30min after anesthetic induction and 15 mins after CPB weaning status
amount of Blood transfusion
intraoperative (during operation) and postoperative (during admission, an expected average of 5 weeks)
- +2 more other outcomes
Eligibility Criteria
Patients undergoing cardiac surgery with Maze-operation
You may qualify if:
- \. Patients who have atrial fibrillation undergoing cardiac surgery with Maze-operation.
- W group : Patients who have had warfarin therapy before operation due to treat Atrial fibrillation
- C group : Patients who have not had warfarin therapy before operation
You may not qualify if:
- \. Patients who have taken medicine related to coagulation (such as antiplatelets like aspirin and clopidogrel) except warfarin or bridged heparin.
- \. Patients whose laboratory values could not be confirmed by medical records review.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Konkuk University Medical Center
Seoul, 143-729, South Korea
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Seong-Hyop Kim, M.D,Ph.D
Konkuk University Medical Center
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 29, 2014
First Posted
July 16, 2014
Study Start
June 1, 2014
Primary Completion
February 1, 2015
Study Completion
February 1, 2015
Last Updated
February 25, 2015
Record last verified: 2015-02