Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease

NCT02190513 | Completed

• 1 other identifier: SJ 0211-07
• Study Type: observational
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics. In recent years, in the literature, several children who underwent upper gastrointestinal endoscopy for suspected CD, which was confirmed histologically, were also found to have coexistent EE. There are reports of coexistent CD and EE. We would like to see the prevalence of EE in children with CD and the prevalence of CD in children with EE in our population, and to do so would like to review medical records. Our objectives are to determine if children with celiac disease have a high prevalence of eosinophilic esophagitis.and to determine if children with eosinophilic esophagitis have increased risk of developing celiac disease.

Conditions

Celiac Disease; Eosinophilic Esophagitis

Outcome Measures

Primary Outcomes (1)

• Review of histopathology reports of esophageal biopsies to record the number of eosinophils per high power field.

  Retrospective chart review study, no contact made with patients, so no patient time is required, expected average of 2 years

Eligibility Criteria

• Age: 2 Years - 21 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children seen in the Pediatric Gastroenterology clinic at St. John Hospital \& Medical Center and diagnosed with celiac disease or eosinophilic esophagitis or both based on the endoscopic and histopathological findings.

You may qualify if:

• Seen in the Pediatric Gastroenterology clinic at St. John Hospital \& Medical Center during study time frame
• Age 2-21 years old
• Diagnosed with CD or EE or both based on the endoscopic and histopathological findings .

You may not qualify if:

• Gastroesophageal reflux diagnosed by PH probe.
• History of chemical ingestion

Sponsors & Collaborators

• St. John Health System, Michigan: lead

MeSH Terms

Conditions

Celiac Disease; Eosinophilic Esophagitis

Condition Hierarchy (Ancestors)

Malabsorption Syndromes; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Esophagitis; Esophageal Diseases; Gastroenteritis; Eosinophilia; Leukocyte Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: tSection Chief of Pediatric Gastroenterology at St. John Hospital and Medical Center

Study Record Dates

• First Submitted: July 10, 2014
• First Posted: July 15, 2014
• Study Start: February 1, 2011
• Primary Completion: June 1, 2013
• Last Updated: July 15, 2014

Record last verified: 2014-07