NCT02187549

Brief Summary

The purpose of this study is to determine whether intra-articular hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
332

participants targeted

Target at P75+ for not_applicable knee-osteoarthritis

Timeline
Completed

Started Jun 2014

Typical duration for not_applicable knee-osteoarthritis

Geographic Reach
1 country

21 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2014

Completed
28 days until next milestone

First Submitted

Initial submission to the registry

June 29, 2014

Completed
12 days until next milestone

First Posted

Study publicly available on registry

July 11, 2014

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2016

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2016

Completed
Last Updated

October 5, 2015

Status Verified

October 1, 2015

Enrollment Period

1.7 years

First QC Date

June 29, 2014

Last Update Submit

October 2, 2015

Conditions

Keywords

Hyaluronic AcidOsteoarthritisKneeHyaluronanViscoelasticHydrogel

Outcome Measures

Primary Outcomes (1)

  • Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Pain Sub-score

    26 weeks

Secondary Outcomes (1)

  • Patient Global Assessment

    26 weeks

Study Arms (2)

HYMOVIS

EXPERIMENTAL

HYADD(TM) 4 Hydrogel Intra-Articular Injection

Device: HYMOVIS

Placebo

PLACEBO COMPARATOR

Saline Intra-Articular Injection

Device: Placebo

Interventions

HYMOVISDEVICE

Intra-articular injection

Also known as: HYADD(TM) 4 Hydrogel Intra-Articular Injection
HYMOVIS
PlaceboDEVICE

Intra-Articular Injection

Also known as: Placebo Intra-Articular Injection
Placebo

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Symptomatic osteoarthritis of the knee.

You may not qualify if:

  • No disorders which could interfere with study required assessments.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (21)

Achieve Clinical Research

Birmingham, Alabama, 35216, United States

Location

Alabama Clinical Therapeutics

Brimingham, Alabama, 35235, United States

Location

Elite Clinical Studies

Phoenix, Arizona, 85018, United States

Location

Arizona Research Center

Phoenix, Arizona, 85023, United States

Location

Med Center

Carmichael, California, 95608, United States

Location

Triwest Research Associates

El Cajon, California, 92020, United States

Location

Westlake Medical

Thousand Oaks, California, 91360, United States

Location

Colorado Orthopedic Consultants

Englewood, Colorado, 80110, United States

Location

Chase Medical

Waterbury, Connecticut, 06708, United States

Location

Riverside Clinical Research

Edgewater, Florida, 32132, United States

Location

Suncoast Clinical Research

New Port Richey, Florida, 34652, United States

Location

Ormond Medical Arts

Ormond Beach, Florida, 32174, United States

Location

Tufts Medical Center

Boston, Massachusetts, 02111, United States

Location

Great Lakes Research Group

Bay City, Michigan, 48706, United States

Location

Healthcare Research Network

Hazelwood, Missouri, 63042, United States

Location

Fabio Orozco

Egg Harbor, New Jersey, 08234, United States

Location

PMG Research of Raleigh

Raleigh, North Carolina, 27609, United States

Location

New Horizons

Cincinnati, Ohio, 45242, United States

Location

Columbus Clinical Research

Columbus, Ohio, 43213, United States

Location

Blair Orphopedics

Altoona, Pennsylvania, 16602, United States

Location

West Houston Clinical Research

Houston, Texas, 77055, United States

Location

MeSH Terms

Conditions

Osteoarthritis, KneeOsteoarthritis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 29, 2014

First Posted

July 11, 2014

Study Start

June 1, 2014

Primary Completion

February 1, 2016

Study Completion

March 1, 2016

Last Updated

October 5, 2015

Record last verified: 2015-10

Locations