Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients

NCT02184494 | Completed Results

• 2 other identifiers: 2014:12658HPN
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 2

Brief Summary

Fatigue is one of the most common and debilitating symptoms experienced in Parkinson's Disease (PD) and Multiple Sclerosis (MS). There are multiple proposed mechanisms of disorder-related fatigue, however, it is unknown whether PD or MS patients experience compromised blood lactate responses to an acute bout of exercise, subjecting them to exercise-related fatigue. These populations may experience higher energy expenditure at rest due to increased rigidity, however, limited data exists investigating resting energy expenditure in these populations. Researchers hypothesize that PD and MS patients will display higher resting energy expenditure than healthy age-matched controls, and that level of energy expenditure will correlate with amount of rigidity or spasticity. Also, we hypothesize that baseline levels of lactate will not be different between PD/MS and control groups, but post-exercise blood lactate levels will be significantly higher in the PD/MS groups.

Conditions

Parkinson's Disease; Multiple Sclerosis

Keywords

Parkinson's Disease; Multiple Sclerosis; Fatigue; Resting Energy Expenditure; Whole Body Vibration; Exercise; Blood Lactate

Outcome Measures

Primary Outcomes (1)

• Blood Lactate Response

  Measured using a blood lactate analyzer, a finger prick test measured before, after, and 10 minutes after exercise

  Before, immediately after, and 10 minutes after the squatting exercise protocol

Secondary Outcomes (1)

• Resting Energy Expenditure

  Measured immediately upon arriving to the laboratory. Lasted approximately 25 minutes.

Other Outcomes (3)

• Neurological Function

  Measured immediately after the resting energy expenditure measurement, and before the other questionnaires. Lasted approximately 15 minutes.

• Health and Activity Questionnaire

  Collected immediately after the UPDRS (if PD population), or immediately after the resting energy expenditure measurement (if MS or healthy, older adult). Measured with other questionnaires and immediately before squatting exercise. Lasted ~10 minutes.

• Fatigue/Depression Assessment

  Collected at the same time as the other questionnaires. Lasted approximately 5-7 minutes.

Study Arms (3)

Blood Lactate Response in PD

EXPERIMENTAL

This arm involves performing 5 sets of 1-minute squats with 1 minute of rest between each, and a finger prick before, after, and 10 minutes after the exercise in a PD population. One set of the squats will be performed on a whole body vibration plate (pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)), and one on the ground.

Device: pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)

Blood Lactate Response in MS

EXPERIMENTAL

This arm involves performing 5 sets of 1-minute squats with 1 minute of rest between each, and a finger prick before, after, and 10 minutes after the exercise in an MS population. One set of the squats will be performed on a whole body vibration plate (pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)), and one on the ground.

Device: pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)

Blood Lactate Responses in Controls

EXPERIMENTAL

This arm involves performing 5 sets of 1-minute squats with 1 minute of rest between each, and a finger prick before, after, and 10 minutes after the exercise in healthy, older adults. One set of the squats will be performed on a whole body vibration plate (pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)), and one on the ground.

Device: pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)

Interventions

pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands) DEVICE

Subjects will be exposed to vertical vibration with a frequency and peak-to-peak displacement of 30 Hz and 1 mm, respectively, which provides a peak-to-peak acceleration of about 4.16 G. Whole Body Vibration

Blood Lactate Response in MS; Blood Lactate Response in PD; Blood Lactate Responses in Controls

Eligibility Criteria

• Age: 45 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Parkinson's Disease Stage I-IV (be standard criteria H\&Y scale)
• Multiple Sclerosis
• Healthy, age-matched controls
• to 90 years old

You may not qualify if:

• Dementia
• Co-morbid neurologic factors
• Individuals without independent ambulation
• Significant heart and respiratory disease
• Debilitating arthritis

Sponsors & Collaborators

• Florida State University: lead

Study Sites (2)

Fitness and Wellness Center

Tallahassee, Florida, 32306, United States

Location

Balance Disorders Clinic

Tallahassee, Florida, 32308, United States

Location

MeSH Terms

Conditions

Parkinson Disease; Multiple Sclerosis; Fatigue; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Results Point of Contact

• Title: Michael J. Ormsbee
• Organization: Florida State University

mormsbee@fsu.edu

6103313126

Study Officials

• Michael J Ormsbee, Ph.D.

  Florida State University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 2, 2014
• First Posted: July 9, 2014
• Study Start: August 1, 2014
• Primary Completion: November 1, 2014
• Study Completion: December 1, 2014
• Last Updated: March 30, 2017
• Results First Posted: November 16, 2015

Record last verified: 2017-03

Data Sharing

• IPD Sharing: Will share

Locations

US (2)