Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke.

NCT02180542 | Completed

• 1 other identifier: Pacific
• Study Type: observational
• Target: 264
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to improve secondary prevention of ischemic stroke patients by

1. 1.Estimating prevalence and the prognostic significance of frequent premature atrial complexes in ischemic stroke patients in relation to death, recurrent stroke and atrial fibrillation.
2. 2.Characterize ischemic stroke patients by
3. 3.Echocardiographic characteristics
4. 4.Biochemical markers
5. 5.Plaque composition in the carotid arteries
6. 6.in order to improve risk stratification.

Conditions

Stroke; Atrial Fibrillation; Premature Atrial Complexes

Keywords

stroke; Ischemic stroke; Cerebral infarction; recurrent stroke; atrial fibrillation; premature atrial complexes; heart rhythm monitoring; left atrial function; carotid artery; plaque morphology

Outcome Measures

Primary Outcomes (1)

• time to death and recurrent stroke

  Up to 4 years

Secondary Outcomes (2)

• Time to death, recurrent stroke and atrial fibrillation

  Up to 4 years

• Left atrial volume and function estimated by echocardiography

  baseline

Other Outcomes (2)

• biochemical markers

  baseline

• Plaque analysis i the carotid arteries on CT

  baseline

Study Arms (1)

Ischemic stroke patients

Patients admitted with ischemic stroke from march 2012 to april 2014

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Ischemic stroke patients admitted to the hospital

You may qualify if:

• admitted with ischemic stroke at a single center
• written informed consent or surrogate informed consent eligible
• age \> 18 years.

You may not qualify if:

• hemorrhagic stroke
• terminal illness and expected lifespan of less than 6 months.
• any physical or mental condition which make the patients unsuitable for participation in the study.
• known with a pacemaker
• anticoagulation treatment of other reasons than atrial fibrillation.

Sponsors & Collaborators

• Odense University Hospital: lead
• University of Southern Denmark: collaborator

Study Sites (1)

Department of Medical Research, OUH, Svendborg

Svendborg, Funen, 5700, Denmark

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Stroke; Atrial Fibrillation; Atrial Premature Complexes; Ischemic Stroke; Cerebral Infarction

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Arrhythmias, Cardiac; Heart Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cardiac Complexes, Premature; Cardiac Conduction System Disease; Brain Infarction; Brain Ischemia; Infarction; Ischemia; Necrosis

Study Officials

• Kristina H Vinther, MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: July 1, 2014
• First Posted: July 2, 2014
• Study Start: March 1, 2012
• Primary Completion: August 1, 2015
• Study Completion: October 1, 2016
• Last Updated: October 11, 2017

Record last verified: 2017-10

Locations

DK (1)