Measurement of Distinct Biological Pools of Hydrogen Sulfide in Women With Cardiovascular Disease

NCT02180074 | Completed

• 1 other identifier: SRKH2SPOOLS
• Study Type: observational
• Target: 137
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular disease which includes coronary artery disease and peripheral artery disease remains the leading cause of death among women in the United States. The impact of cardiovascular in women was not recognized by clinicians for a long time. It is now evident that, women suffer the consequences of cardiovascular at rates at least as high as those observed in men but there are still major gaps in our understanding this disease in women. Hydrogen sulfide (H2S), a gaseous mediator plays an important role in the cardiovascular system. Research has demonstrated it's critical role in animal ischemia reperfusion models. Hydrogen sulfide exists in distinct biological pools in blood. Recently, the Kevil lab has pioneered the development of new analytical techniques for accurate measurement of all biological pools of H2S. By measuring these distinct pools of H2S in women with and without cardiovascular disease the investigators hope to further understanding of role of H2S in pathophysiology of cardiovascular disease. This research will help to assess the ability of H2S and its distinct biological pools to potentially be a diagnostic marker or a therapeutic target for cardiovascular disease.

Conditions

Cardiovascular Disease

Keywords

Hydrogen Sulfide Pools,

Outcome Measures

Primary Outcomes (1)

• Free Sulfide, Bound Sulfide and Acid Labile Sulfide

  Unit of Measure: nMol

  1 year

Study Arms (5)

I

Women without PAD (ABI \>1.0 and \<1.4) or CAD, and \< 2 risk factors for cardiovascular disease (to serve as healthy controls)

II

Women without PAD (ABI\>1.0 and \<1.4) or CAD and \> 2 risk factors for cardiovascular disease

III

Women with PAD as defined by ABI \<0.9 and a coronary angiogram without any significant coronary artery disease.

IV

Women with CAD without PAD, as defined by \>50% stenosis by coronary angiography and ABI \>1.0 and \<1.4.

V

Women with both CAD and PAD.

Eligibility Criteria

• Age: 40 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Female subjects scheduled to undergo left heart catheterization or peripheral angiography at LSUHSC Shreveport cardiac catheterization laboratory will be given the opportunity to participate. Controls will be recruited via flyers posted in various parts of LSUHSC Shreveport.

You may qualify if:

• Patients presenting to the cardiac catheterization laboratory for coronary or peripheral angiography.
• Females,Age\>40years

You may not qualify if:

• Inability to provide informed consent.
• STelevationmyocardialinfarction.
• Cardiogenicshock.
• \. ABI \>1.4 (indicative of non-compressible vessel needing further evaluation to diagnose PAD), unless documented known PAD. 4. Non-atheroscleroticPAD(e.g.Buerger'sdisease). 5. Enrolment in another clinical trial with use of experimental therapeutic agents.

Sponsors & Collaborators

• Louisiana State University Health Sciences Center Shreveport: lead

Study Sites (1)

LSUHSC

Shreveport, Louisiana, 71103, United States

Location

Related Publications (4)

• Mosca L, Ferris A, Fabunmi R, Robertson RM; American Heart Association. Tracking women's awareness of heart disease: an American Heart Association national study. Circulation. 2004 Feb 10;109(5):573-9. doi: 10.1161/01.CIR.0000115222.69428.C9. Epub 2004 Feb 4.

  PMID: 14761901 BACKGROUND

• Hirsch AT, Allison MA, Gomes AS, Corriere MA, Duval S, Ershow AG, Hiatt WR, Karas RH, Lovell MB, McDermott MM, Mendes DM, Nussmeier NA, Treat-Jacobson D; American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular Nursing; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology; Council on Epidemiology and Prevention. A call to action: women and peripheral artery disease: a scientific statement from the American Heart Association. Circulation. 2012 Mar 20;125(11):1449-72. doi: 10.1161/CIR.0b013e31824c39ba. Epub 2012 Feb 15. No abstract available.

  PMID: 22343782 BACKGROUND

• Shen X, Pattillo CB, Pardue S, Bir SC, Wang R, Kevil CG. Measurement of plasma hydrogen sulfide in vivo and in vitro. Free Radic Biol Med. 2011 May 1;50(9):1021-31. doi: 10.1016/j.freeradbiomed.2011.01.025. Epub 2011 Jan 27.

  PMID: 21276849 BACKGROUND

• Shen X, Peter EA, Bir S, Wang R, Kevil CG. Analytical measurement of discrete hydrogen sulfide pools in biological specimens. Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2276-83. doi: 10.1016/j.freeradbiomed.2012.04.007. Epub 2012 Apr 19.

  PMID: 22561703 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma.

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Christopher Kevil, PhD

  LSUHSC Shreveport

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 18, 2014
• First Posted: July 2, 2014
• Study Start: September 1, 2013
• Primary Completion: May 7, 2017
• Study Completion: May 7, 2017
• Last Updated: September 2, 2021

Record last verified: 2014-06

Locations

US (1)