Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

NCT02179437 | Completed

• 1 other identifier: UW14-356
• Study Type: observational
• Target: 95
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain can be severe after liver resection surgery. However, postoperative pain management may be difficult for this group of patients. Opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. Large dose of strong opioid may be required to achieve adequate pain control. However, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection. Propofol is a commonly used anaesthetic with rapid recovery and less side effects and TIVA (total intravenous analgesia) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery. Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result. The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing liver resection surgery at Queen Mary Hospital, Hong Kong between 2010 to 2012.

Conditions

Postoperative Pain

Keywords

TIVA; Propofol; Postoperative pain; Liver resection surgery; Retrospective study

Outcome Measures

Primary Outcomes (1)

• Postoperative pain score

  From postoperative 1 hour to postoperative 72 hour

Secondary Outcomes (1)

• Adverse event

  From postoperative 1 hour to postoperative 72 hour

Other Outcomes (1)

• Analgesic consumption

  From postoperative 1 hour to postoperative 72 hour

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

You may qualify if:

• Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

You may not qualify if:

• Essential data were missing.
• Patient participating in other research projects.
• Changes in postoperative pain management technique.
• Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Department of Anaesthesiology, The University of Hong Kong

Hong Kong, Hong Kong, China

Location

Related Publications (1)

• Chan AC, Qiu Q, Choi SW, Wong SS, Chan AC, Irwin MG, Cheung CW. Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study. PLoS One. 2016 Feb 22;11(2):e0149753. doi: 10.1371/journal.pone.0149753. eCollection 2016.

  PMID: 26901037 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Chi Wai Cheung, MD

  Department of Anaesthesiology, The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: June 27, 2014
• First Posted: July 1, 2014
• Study Start: August 1, 2014
• Primary Completion: February 22, 2016
• Study Completion: February 22, 2016
• Last Updated: May 16, 2024

Record last verified: 2024-05

Locations

CN (1)