Test-Retest Variability of Quick Contrast Sensitivity Function Testing

NCT02177669 | Completed

• 3 other identifiers: 05291468ExpR21EY023720Adaptive Sensory Technology
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The contrast sensitivity function (CSF) provides a comprehensive characterization of spatial vision and predicts functional vision better than visual acuity, but long testing times prevent its psychophysical assessment in clinical applications. Dr. Luis Lesmes et al. (2010) developed the qCSF method to obtain precise CSF measurements in only 30-50 trials using a computerized software program that presents letters on a large monitor that are identified by a patient similar to typical visual acuity testing with an eye chart. The quick CSF method is a Bayesian adaptive method that estimates the full shape of the CSF, and the test duration is only about 3-6 minutes. Some preliminary testing has been performed at other sites with this test in patients with vision loss due to amblyopia and glaucoma, but data from individuals without eye disease who have normal visual acuity has not been systematically collected with the latest version of this test procedure across a wide range of ages. In addition, we aim to gain a better understanding of the typical test-retest variability that is obtained between-sessions that are about a week apart from individuals with good ocular health and visual acuity.

Conditions

Healthy

Keywords

Normal, healthy individuals without ocular disease; Ages 20-89; English speaking; Visual acuity better than 20/25

Outcome Measures

Primary Outcomes (1)

• 95% coefficient of repeatability across subjects

  We will evaluate various contrast sensitivity metrics that are generated by the computer program: (i) AULCSF or area under the curve for the log contrast sensitivity function (CSF), (ii) CSF acuity or the cutoff-frequency at which sensitivity=2.0 is calculated, and (iii) contrast sensitivity at various spatial frequencies (i.e. 1.5, 3, 6, 12, 18.5 cycles per degree), obtained with testing performed binocularly, with the better eye monocularly, and with the better eye using a NoIR 4% transmission filter. Within subject, the data will be analyzed as differences between the two values obtained at the two sessions, which can then be used to determine a 95% coefficient of repeatability across subjects.

  test-retest at 2 visits about a week apart

Study Arms (1)

Normals without ocular disease

Other: quick Contrast Sensitivity Function test

Interventions

quick Contrast Sensitivity Function test OTHER

Normals without ocular disease

Eligibility Criteria

• Age: 20 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals between the ages of 20-89 without ocular disease will be recruited from among patients seen in the Primary Eye Care Clinic at the Nova Southeastern University's The Eye Care Institute in Davie-Ft. Lauderdale, FL, as well as faculty, students and staff at this institution.

You may qualify if:

• Ages 20-89
• Normal distance visual acuity in each of both eyes (20/20)
• Absence of ocular disease
• Able and willing to complete contrast sensitivity testing
• Provide informed consent

You may not qualify if:

• Any ocular disease
• Refractive errors \>6D
• Inability to understand study or communicate responses (cognitive impairment)
• Unable to understand, read and speak English fluently

Sponsors & Collaborators

• Nova Southeastern University: lead
• Adaptive Sensory Technology: collaborator

Study Sites (1)

Nova Southeastern University; College of Optometry

Fort Lauderdale, Florida, 33328, United States

Location

Related Publications (2)

• Dorr M, Lesmes LA, Lu ZL, Bex PJ. Rapid and reliable assessment of the contrast sensitivity function on an iPad. Invest Ophthalmol Vis Sci. 2013 Nov 5;54(12):7266-73. doi: 10.1167/iovs.13-11743.

  PMID: 24114545 BACKGROUND

• Lesmes LA, Lu ZL, Baek J, Albright TD. Bayesian adaptive estimation of the contrast sensitivity function: the quick CSF method. J Vis. 2010 Mar 30;10(3):17.1-21. doi: 10.1167/10.3.17.

  PMID: 20377294 BACKGROUND

Study Officials

• Ava K Bittner, OD, PhD

  Nova Southeastern University; College of Optometry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 26, 2014
• First Posted: June 30, 2014
• Study Start: June 1, 2014
• Primary Completion: November 1, 2016
• Study Completion: November 1, 2016
• Last Updated: April 11, 2017

Record last verified: 2017-04

Locations

US (1)