Interval Versus Continuous Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease

NCT02168712 | Completed

• 1 other identifier: EO31/2013-HIE
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise therapy increase functional capacity improving the morbidity and mortality of patients with cardiovascular disease. Moderate continuous training is the best established training modality for this patients. However, a body of evidence has begun to emerge demonstrating that high intensity interval training obtained better results in terms of morbidity and mortality. The purpose of this randomized clinical trial was to determine the effect of two types of exercise training: moderate continuous training vs high interval training on functional capacity and quality of life as well as verify the safety in its application. We included 72 patients with coronary artery disease by assigning one of the training modality for 8 weeks. We analyzed cyclo-ergo-spirometry data, aspect related to quality of life as well as a record of adverse events.

Conditions

Coronary Heart Disease

Keywords

Coronary Heart Disease; Interval exercise training; Continuous exercise training; Quality of life; Safety

Outcome Measures

Primary Outcomes (1)

• Impact on functional capacity

  Basal and peak oxygen consumption values will be measured.

  2 months

Secondary Outcomes (1)

• quality of life

  2 months

Other Outcomes (1)

• Incidence of Adverse Events

  2 months

Study Arms (2)

Moderate continuous exercise training

ACTIVE COMPARATOR

Moderate intensity continuous exercise training

Other: Moderate continuous exercise training

Interval exercise training

EXPERIMENTAL

High intensity interval exercise training

Other: Interval exercise training

Interventions

Moderate continuous exercise training OTHER

Moderate continuous exercise training

Interval exercise training OTHER

Interval exercise training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Coronary heart Disease, with functional class II-III according to New York Heart Association classification system.
• At least 4 weeks from acute cardiac event, percutaneous or surgery revascularization.
• Optimized medical treatment in adequate doses ( betablockers, ACE inhibitors, ARA II, statins and antiplatelet drugs)
• Age \> 18 years old.
• Willing to participate and sign an informed consent form

You may not qualify if:

• Residual ischemia waiting for revascularization.
• Any cardiac event for the last 4 weeks
• Abnormal Ergometry with hemodynamic or clinically significant arrhythmias during the procedure.
• History of severe ventricular arrhythmia
• Uncontrolled glycaemia or blood pressure
• Moderate to severe Chronic Pulmonary Obstructive Disease
• Osteomuscular and/or mental disorder that hampers an adequate adherence to the intervention program
• Other vascular diseases: rheumatologic/ autoimmune disorders, thrombopathies, hemophilia.
• Active oncologic disease.
• Treatment with corticosteroids.

Sponsors & Collaborators

• Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz: lead

Study Sites (1)

Hospital Infanta Elena

Valdemoro, Madrid, 28342, Spain

Location

MeSH Terms

Conditions

Coronary Disease

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of Rehabilitation Department

Study Record Dates

• First Submitted: June 16, 2014
• First Posted: June 20, 2014
• Study Start: November 1, 2011
• Primary Completion: April 1, 2014
• Study Completion: April 1, 2014
• Last Updated: June 20, 2014

Record last verified: 2014-06

Locations

ES (1)