Correlation Between Power Doppler and Intraoperative Findings of Chronic and Acute Cholecystitis
Correlation Between Preoperative Power Doppler Sonography and Intraoperative Findings - Postoperative Outcomes of Chronic and Acute Cholecystitis Patients: Prospective Clinical Study
2 other identifiers
observational
80
1 country
1
Brief Summary
In theory, increased vascularity of GB wall could be associated with intraoperative findings, such as, GB wall inflammation and accompanying adhesions. There are not enough reports in the literature describing the correlation between GB wall vascularity and operative findings according to adhesion scoring scale. In this prospective clinical study, we aimed to highlight the correlation between preoperative power Doppler sonography detected GB wall vascularity and intraoperative findings - postoperative outcomes of chronic and acute cholecystitis patients.
Trial Health
Trial Health Score
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participants targeted
Target at P50-P75 for all trials
Started Jan 2012
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 1, 2014
CompletedFirst Posted
Study publicly available on registry
June 5, 2014
CompletedJune 5, 2014
June 1, 2014
1.5 years
June 1, 2014
June 3, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Correlation between wall thickness-vascularity and adhesion grade
Correlation between gallbladder wall thickness - vascularity (as measured by quantative measurement scale of gallbladder wall vascularity) and intraoperative adhesion grade (as measured by gallbladder adhesion scoring scale) of chronic and acute cholecystitis patients.
Up to ten days
Secondary Outcomes (6)
Correlation between vascularity and gallbladder perforation
Up to ten days
Correlation between vascularity and convertion
Up to ten days
Correlation between vascularity and operation time
Up to ten days
Correlation between vascularity and drain usage
Up to ten days
Correlation between vascularity and specimen
Up to twenty days
- +1 more secondary outcomes
Study Arms (2)
Chronic cholecystitis
Laparoscopic cholecystectomy was performed. Gallbladder adhesion score and intraoperative findings of patients were assessed. Adhesion score, gallbladder perforation during the dissection, convertion to open cholecystectomy, operation time, drain usage and intraoperative complications were recorded.
Acute cholecystitis
Laparoscopic cholecystectomy was performed. Gallbladder adhesion score and intraoperative findings of patients were assessed. Adhesion score, gallbladder perforation during the dissection, convertion to open cholecystectomy, operation time, drain usage and intraoperative complications were recorded.
Interventions
The technique used for LC was the conventional four-trocar approach (10-mm optic at the umbilicus, 10-mm trocar in the epigastrium and two 5-mm trocars in the right upper abdomen).
Eligibility Criteria
A total of 80 cholecystitis patients (40 symptomatic chronic, 40 acute).
You may qualify if:
- Symptomatic chronic cholelithiasis patients, who were accepted to laparoscopic cholecystectomy
- Acute cholelithiasis patients, who were accepted to laparoscopic cholecystectomy in first 72-96 hours (from the onset of symptoms), Acute cholecystitis diagnosis was made according to; acute right upper quadrant abdominal pain with positive Murphy's sign, fever, leukocytosis and sonographically; distended GB, presence of gallstones or sludge, GB wall thickness of 3-mm or more, sonographic Murphy's sign.
You may not qualify if:
- Choledocholithiasis
- \<18 years old
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Adana Numune Education and Research Hospital, Adana, Turkey
Adana, Turkey (Türkiye)
Related Publications (4)
Ralls PW, Colletti PM, Lapin SA, Chandrasoma P, Boswell WD Jr, Ngo C, Radin DR, Halls JM. Real-time sonography in suspected acute cholecystitis. Prospective evaluation of primary and secondary signs. Radiology. 1985 Jun;155(3):767-71. doi: 10.1148/radiology.155.3.3890007.
PMID: 3890007BACKGROUNDUggowitzer M, Kugler C, Schramayer G, Kammerhuber F, Groll R, Hausegger KA, Ratschek M, Quehenberger F. Sonography of acute cholecystitis: comparison of color and power Doppler sonography in detecting a hypervascularized gallbladder wall. AJR Am J Roentgenol. 1997 Mar;168(3):707-12. doi: 10.2214/ajr.168.3.9057520.
PMID: 9057520BACKGROUNDAkoglu M, Ercan M, Bostanci EB, Teke Z, Parlak E. Surgical outcomes of laparoscopic cholecystectomy in scleroatrophic gallbladders. Turk J Gastroenterol. 2011;22(2):183-9. doi: 10.4318/tjg.2011.0188.
PMID: 21796556BACKGROUNDCetinkunar S, Erdem H, Aktimur R, Soker G, Bozkurt H, Reyhan E, Sozen S, Irkorucu O. Evaluation of power Doppler sonography in acute cholecystitis to predict intraoperative findings: a prospective clinical study. Ulus Travma Acil Cerrahi Derg. 2015 Jan;21(1):51-6. doi: 10.5505/tjtes.2015.64505.
PMID: 25779713DERIVED
Biospecimen
Resected gallbladders pathology
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Recep Aktimur
Samsun Education and Research Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr.
Study Record Dates
First Submitted
June 1, 2014
First Posted
June 5, 2014
Study Start
January 1, 2012
Primary Completion
July 1, 2013
Study Completion
July 1, 2013
Last Updated
June 5, 2014
Record last verified: 2014-06