Activity in Tourette Syndrome

NCT02153463 | Completed

• 1 other identifier: 14/72X
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

Tics are brief repetitive movements or vocalizations. Gilles de la Tourette's syndrome (TS) is a disorder characterized by recurrent motor and vocal tics. Tourette syndrome and tic disorders affect up to 8% of children. Peak severity of tic disorders occurs between the ages of 8 to 12 years, therefore during childhood and adolescence the most significant impacts are felt. The quality of life of young people with tics is lower than their peers' and tic severity predicts lower quality of life. Studies have also shown negative social perception toward children with tics. Approximately 50% of patients with Tourette syndrome will have other diagnoses including attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, anxiety and depression. Studies have shown improvements in ADHD with physical activity. ADHD and tic disorders are thought to involve the same areas of the brain; thus it is possible that tics might also improve with physical activity. However, no studies to date have examined this. The investigators predict that by implementing a motivational physical activity program, in conjunction with physical activity counseling, the investigators will be able to increase levels of physical activity in children with tics and Tourette syndrome, with a positive impact on tic severity.

Conditions

Tourette Syndrome; Persistent Tic Disorder

Keywords

Tourette Syndrome; Persistent Tic Disorder; Physical Activity; Quality of Life

Outcome Measures

Primary Outcomes (1)

• Decrease in Yale Global Tic Severity Scale.

  8 weeks

Secondary Outcomes (1)

• Change in The Gilles de la Tourette Syndrome Quality of Life Scale for children and adolescents

  8 weeks

Other Outcomes (4)

• Change in PedsQL 4.0 measure

  8 weeks

• Change in KidScreen-27

  8 weeks

• Chang in The Children's Self-perceived Adequacy and Predilection for Physical Activity Questionnaire

  8 Weeks

Study Arms (2)

Activity Counselling

EXPERIMENTAL

Physical Activity Counselling weekly for 8 weeks

Behavioral: Physical Activity Counselling

Standard Care

NO INTERVENTION

Standard care with no change in medications for 8 weeks

Interventions

Physical Activity Counselling BEHAVIORAL

Physical Activity Counselling weekly for 8 weeks

Activity Counselling

Eligibility Criteria

• Age: 8 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Participants are between 8-16 years of age.
• Participants are required to have a diagnosis of either Tourette Syndrome or Persistent (Chronic) Motor of Vocal Tic Disorder as per the DSM V.
• Participants must be ambulatory.
• Participants and parents must understand English or French.
• Participants must be able and willing to complete the questionnaires.
• Participants cannot have any changes to their medication for tics, or any other psychotropic medications for 4 weeks prior to and for the entire duration of the study

You may not qualify if:

• Participants who cannot ambulate independently.
• Participants who are not permitted to participate in physical education class at school.
• Participants or families who are not willing to be randomly assigned to a study group.

Sponsors & Collaborators

• Children's Hospital of Eastern Ontario: lead

Study Sites (1)

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 7G2, Canada

Location

Related Publications (1)

• Doja A, Bookwala A, Pohl D, Rossi-Ricci A, Barrowman N, Chan J, Longmuir PE. Relationship Between Physical Activity, Tic Severity and Quality of Life in Children with Tourette Syndrome. J Can Acad Child Adolesc Psychiatry. 2018 Nov;27(4):222-227. Epub 2018 Nov 1.

  PMID: 30487937 DERIVED

MeSH Terms

Conditions

Tourette Syndrome; Motor Activity

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Associate Investigator

Study Record Dates

• First Submitted: May 30, 2014
• First Posted: June 3, 2014
• Study Start: May 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: August 6, 2015

Record last verified: 2015-08

Locations

CA (1)