NCT02146898

Brief Summary

The investigators intend to study the impact of patient positioning on the changes in blood pressure after spinal anesthesia for cesarean delivery. The investigators hypothesized that the changes in blood pressure relate to the speed with which the spinal medication rises. By slowing the rise of spinal anesthesia, the investigators believe that the incidence and severity of hypotension might be reduced.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
105

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2013

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

May 19, 2014

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 26, 2014

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
Last Updated

January 4, 2017

Status Verified

January 1, 2017

Enrollment Period

3.3 years

First QC Date

May 19, 2014

Last Update Submit

January 3, 2017

Conditions

Keywords

spinal anesthesiahypotensionpregnancy

Outcome Measures

Primary Outcomes (1)

  • change in blood pressure

    percentage change in blood pressure after spinal anesthesia

    20 minutes

Secondary Outcomes (1)

  • IV fluid administration

    20 minutes

Other Outcomes (1)

  • IV pressor requirements

    20 minutes

Study Arms (3)

Lateral

ACTIVE COMPARATOR

patient placed in the lateral postion for spinal anesthesia

Other: Position

Sitting

ACTIVE COMPARATOR

patient placed in the sitting position for spinal anestheisa, then supine

Other: Position

Recline

ACTIVE COMPARATOR

patient placed in the sitting position for spinal anesthesia administration. After spinal placed, the patient turned to a 30-degree upperbody tilt, followed by a slow recline to supine over 5 minutes

Other: Position

Interventions

LateralReclineSitting

Eligibility Criteria

Age18 Years - 50 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Singleton pregnancy
  • Term gestation
  • Scheduled cesarean delivery
  • Spinal anesthesia for delivery

You may not qualify if:

  • Significant fetal concerns
  • Polyhydramnios
  • Macrosomia
  • Morbid obesity (BMI \>40)
  • Chronic hypertension
  • Gestational hypertension
  • Preeclampsia
  • Type 1 diabetes
  • Contraindications to spinal anesthesia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beth Isreal Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

MeSH Terms

Conditions

Hypotension

Interventions

Patient Positioning

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Patient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and Services

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chief of Obstetric Anesthesia

Study Record Dates

First Submitted

May 19, 2014

First Posted

May 26, 2014

Study Start

September 1, 2013

Primary Completion

December 1, 2016

Study Completion

December 1, 2016

Last Updated

January 4, 2017

Record last verified: 2017-01

Data Sharing

IPD Sharing
Will not share

Locations