Predictor of Residual Neuromuscular Blockade in Recovery Room After General Anesthesia

NCT02146859 | Completed

• 1 other identifier: Si123
• Study Type: observational
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

Background When general anesthesia was performed, neuromuscular blocking agents (NMBAs) are frequently used for facilitate tracheal intubation and keep patient still and relax during surgery. Unfortunately, residual neuromuscular blockade are important complication. There are many factors that affect neuromuscular blockade and may prolong effect of NMBAs which we already know about that such as body temperature, drugs, some kind of diseases. However there are no recent studies that mention about other factors. The purpose of this study is to find out other factors that affect NMBAs effect to improve patient safety. Methods The study is a prospective, non-randomized, blinded, observational study. 222 patients will be included in this study and will be performed general anesthesia. Anesthetic technique and agent which are used depend on regular staff. Information of patient will be collected are age, sex, weight, height, ASA classification, anesthetic technique, anesthetic and surgical time, amount of inhalation agent, amount of NMBAs, amount of opioids and reversal agents. After anesthesia finish, patient will be brought to recovery room and Train Of Four watch® will be placed and record Train Of Four ratio by this research staff. Train Of Four ratio \< 0.9 will be defined as there is residual neuromuscular blockade in this patient. All patients will be divided into 2 groups: residual blockade group(patient who have train of four \<0.9 after surgery) and no residual blockade group(patient who have train of four \>0.9). All factor of each group will be compared between. Statistical will be analyzed to find significant factor which affect neuromuscular blockade.

Conditions

Residual Neuromuscular Blockade

Keywords

residual neuromuscular blockade

Outcome Measures

Primary Outcomes (1)

• residual neuromuscular blockade after surgery

  residual neuromuscular blockade after surgery measure by train of four of nervestimulator

  1 hour

Study Arms (1)

general anesthesia

Patient having general anesthesia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patient who are schedule for general anesthesia and use neuromuscular blocking agents (NMBAs)

You may qualify if:

• \- age ≥ 18 years
• American society of anesthesiologist class I-III
• patient who are schedule for intraabdominal surgery, orthopedic surgery and gynecologic surgery under general anesthesia and use neuromuscular blocking agents (NMBAs)

You may not qualify if:

• \- patients who have myasthenia gravis, myotonia, muscular dystrophy, upper motor neuron lesion
• patients who have drug which influence neuromuscular action such as oral muscle relaxant, anticonvulsants, magnesium sulfate
• Body temperature \>37.8 or \< 36 degree Celsius before operation

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of medicine Siriraj hospital

Bangkok, 10700, Thailand

Location

MeSH Terms

Conditions

Delayed Emergence from Anesthesia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Instructor

Study Record Dates

• First Submitted: May 16, 2014
• First Posted: May 26, 2014
• Study Start: May 1, 2014
• Primary Completion: January 1, 2017
• Study Completion: March 1, 2017
• Last Updated: March 27, 2018

Record last verified: 2018-03

Locations

TH (1)