NCT02140957

Brief Summary

Observational studies support an association between bottle feeding beyond 15 to 18 months of age and lower socioeconomic status, excessive milk intake, dental caries, iron deficiency, behavioral issues and obesity. Yet many parents, particularly those from low socioeconomic households, choose to feed their children by bottle much beyond this age. Recognizing the need for further educational interventions for bottle feeding, the TARGet Kids! Research Collaboration recently developed a 5-minute bottle weaning educational intervention for the 9 month well-child visit. We undertook a pragmatic randomized controlled trial to evaluate its effectiveness involving 251 children recruited through TARGet Kids! (PMID: 20624802) The goal was to determine whether an office-based, educational intervention for parents of 9-month-old children could reduce bottle use and iron depletion at 2 years of age.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
251

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2007

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2009

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

August 19, 2013

Completed
9 months until next milestone

First Posted

Study publicly available on registry

May 16, 2014

Completed
1.7 years until next milestone

Results Posted

Study results publicly available

February 5, 2016

Completed
Last Updated

February 5, 2016

Status Verified

January 1, 2016

Enrollment Period

2.7 years

First QC Date

August 19, 2013

Results QC Date

November 23, 2015

Last Update Submit

January 6, 2016

Conditions

Keywords

Toddler Bottle UseEducational InterventionPediatricsIron Deficiency

Outcome Measures

Primary Outcomes (1)

  • Change in Iron Depletion

    Iron depletion (serum ferritin \< 10 μg/L).

    Baseline, 2 years

Secondary Outcomes (2)

  • Current Bottle Use

    2 years

  • Current Nighttime Bottle Use

    2 years

Study Arms (2)

Educational Intervention

EXPERIMENTAL

Parents in this arm received a 5 minute educational intervention on bottle cessation plus standard nutritional counseling.

Behavioral: Educational Intervention

Control

PLACEBO COMPARATOR

Parents in this arm received a placebo which consisted of standard nutritional counseling alone.

Behavioral: Educational Intervention

Interventions

Parents of children in both intervention and control groups received standardized counseling on healthy nutrition based on Canadian Paediatric Society guidelines. In addition, during the same 9-month doctors visit, parents of infants allocated to the intervention group were given a sip cup (Avent Magic CupTM) and shown how to use it. A trained research assistant told intervention group parents the risks of continued bottle use. They were also instructed to limit daily milk consumption to 16 ounces. Parents were also counseled to discontinue bottle use in the next 1 week using a step-wise protocol described on a handout to be placed on their refrigerator. Parents of infants allocated to the control group did not receive this information.

ControlEducational Intervention

Eligibility Criteria

Age6 Months - 1 Year
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Children and their families who participated in The Applied Research Group for Kids (TARGet Kids!) pragmatic RCT

You may not qualify if:

  • N/A

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

Location

MeSH Terms

Conditions

Iron Deficiencies

Interventions

Early Intervention, Educational

Condition Hierarchy (Ancestors)

Iron Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Child Health ServicesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and ServicesPreventive Health Services

Results Point of Contact

Title
Dr. Jonathon Maguire
Organization
St. Michael's Hospital

Study Officials

  • Jonathon Maguire, MD

    The Hospital for Sick Children

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Staff Physician

Study Record Dates

First Submitted

August 19, 2013

First Posted

May 16, 2014

Study Start

January 1, 2007

Primary Completion

September 1, 2009

Study Completion

October 1, 2009

Last Updated

February 5, 2016

Results First Posted

February 5, 2016

Record last verified: 2016-01

Locations