Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction
SPEEDCARS
Cross Sectional Study of Use of Speckle Tracking Echocardiography in the Early Diagnosis of Cardiovascular Dysfunction and Performance in Sjogren Patients
1 other identifier
observational
700
1 country
2
Brief Summary
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2010
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2014
CompletedFirst Submitted
Initial submission to the registry
May 5, 2014
CompletedFirst Posted
Study publicly available on registry
May 7, 2014
CompletedMay 7, 2014
February 1, 2014
3.2 years
May 5, 2014
May 5, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Longitudinal Myocardial Strain reduction in Sjogren Patients
Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction)
Baseline, 24 weeks
Secondary Outcomes (1)
Association between 6minute-walking-test and Longitudinal strain reduction
baseline, 24 weeks
Study Arms (2)
Sjogren
Sjogren Patients evaluated with Speckle tracking echocardiography
Control
Controls Speckle tracking echocardiography
Interventions
Eligibility Criteria
Consecutive patients enrolled from cardiovascular clinic
You may qualify if:
- Diagnosis of Sjogren Syndrome
You may not qualify if:
- previous cardiovascular events
- unstable angina
- stroke
- diagnosis of heart failure
- incapacity to provide an informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Galeazzi IRCCS of Milan
Milan, Italy, Italy
Sapienza University
Rome, Italy
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
May 5, 2014
First Posted
May 7, 2014
Study Start
January 1, 2010
Primary Completion
March 1, 2013
Study Completion
May 1, 2014
Last Updated
May 7, 2014
Record last verified: 2014-02