Metabolic Costs of Daily Activities in Older Adults

NCT02129855 | Completed DMC

• 4 other identifiers: IRB201501057-N5R01AG042525-05087-2013OCR15164
• Study Type: observational
• Target: 269
• Locations: 1 country
• Sites: 1

Brief Summary

The work will evaluate the metabolic costs for daily activities across the lifespan and evaluate the influence of having functional impairments.

Conditions

Functional Limitation

Outcome Measures

Primary Outcomes (4)

• MET value

  MET value of physical activities defined as the oxygen uptake (VO2 = milliliter• min-1•kg-1) during a steady state rate expressed as a function 3.5 milliliter• min-1•kg-1.

  Participants will attend up to 4 visits within one month of enrollment to attain these data

• Metabolic economy

  Metabolic economy is the energy expended for a given work rate.

  Participants will attend up to 4 visits within one month of enrollment to attain these data

• Relative metabolic cost to peak energy expenditure

  Relative metabolic cost is function of peak oxygen consumption

  Participants will attend up to 4 visits within one month of enrollment to attain these data

• Relative metabolic cost to resting energy expenditure

  Relative metabolic cost as a function of resting

  Participants will attend up to 4 visits within one month of enrollment to attain these data

Secondary Outcomes (1)

• Rating of perceived exertion

  Participants will attend up to 4 visits within one month of enrollment to attain these data

Other Outcomes (1)

• Accelerometer signals to predict of energy expenditure

  Participants will attend up to 4 visits within one month of enrollment to attain these data

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community dwelling population

You may qualify if:

• Age 20+ years old
• Community dwelling adults without significant health issues
• Willingness to undergo all testing procedures
• Weight stable for at least three months
• Able to understand and speak English

You may not qualify if:

• Failure to provide informed consent
• A 10% enrollment limit will be applied to avid exercisers in each age decade. Avid exercises will be defined as doing structured exercise 3 or more days per week (e.g. jogging, sports etc., walkers will be permitted in the study). Based on our experience, avid exercisers volunteer for this type of research at a high rate and thus the investigators will limit these individuals to prevent a biased comparison
• Use of walker (use of a cane is permitted)
• Lower extremity amputation
• Develops chest pain or severe shortness of breath during physical stress
• Post-stroke syndrome causing ambulatory deficits (other stroke survivors permitted)
• Pacemaker
• Needs assistance with basic activities of daily living: feeding, dressing, continence, bathing, toileting, and transferring from a bed to a chair or from a chair to walking
• Lives in a nursing home; persons living in assisted or independent housing are not excluded
• For adults over the age of 60: \>2 errors on the Short, portable mental status questionnaire administered after written informed consent
• Excessive alcohol or substance abuse within six months or consumption of \>14 alcohol drinks/week
• For women who are child-bearing age (up to 62 years of age): pregnant or breast-feeding
• Participation in a structured weight loss program or fad diet in the last month;
• Weight reduction surgery in the past year
• Known neuromuscular disorder (Rhabdomyolysis, Myasthenia Gravis, Ataxia, Apraxia, post-polio syndrome, mitochondrial myopathy, chronic fatigue syndrome etc.)

Sponsors & Collaborators

• University of Florida: lead
• Wake Forest University: collaborator
• National Institute on Aging (NIA): collaborator

Study Sites (1)

UF Institute on Aging Clinical and Translational Research Building

Gainesville, Florida, 32611, United States

Location

Related Links

• University of Florida Institute on Aging

Study Officials

• Todd M Manini, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 28, 2014
• First Posted: May 2, 2014
• Study Start: July 1, 2014
• Primary Completion: June 6, 2019
• Study Completion: June 6, 2019
• Last Updated: June 7, 2019

Record last verified: 2019-06

Locations

US (1)