Mentalization-Based Therapy to Prevent Suicidal Behavior in Adolescents With Bipolar Disorder

NCT02129790 | Completed DMC

• 1 other identifier: 13-000988
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Children and adolescents with early-onset bipolar disorder (BD) are at high risk for intentionally hurting themselves. Although there are therapies in existence for these youths with BD, they do not address suicide prevention specifically. Mentalization-based therapy for adolescents (MBT-A) has been shown to be helpful in reducing self-harm in the adolescent and adult population with borderline personality disorder. The investigators will modify the MBT-A treatment procedures for persons with BD who have had a recent period of suicidal ideation or behavior.

Conditions

Bipolar Disorder; Suicidal Ideation

Keywords

Bipolar Disorder; Suicidal; Depression; Self-harm; Psychosocial intervention

Outcome Measures

Primary Outcomes (1)

• Self-harm Scores

  Self-harm is a composite score derived from two Kiddie Schedule for Affective Disorders and Schizophrenia Depression Rating Scale items, total scores on the Harkavy-Asnis Suicide Scale, total scores on the Risk and Self-Harm Scale, and specific levels of ideation or behavior on the Columbia Suicide and Self-Harm Scale.

  measured every 3 months for 9 months

Secondary Outcomes (2)

• Treatment completion

  first 6 study months

• Depression scores

  every 3 months for 9 months

Study Arms (1)

Mentalization-Based Therapy

EXPERIMENTAL

Up to 21 individual MBT-A sessions plus 9 monthly family sessions. MBT-A will include psychoeducation and coping strategies.

Behavioral: Mentalization-Based Therapy

Interventions

Mentalization-Based Therapy BEHAVIORAL

Up to 21 individual MBT-A sessions plus 9 monthly family sessions. MBT-A sessions will focus on the adolescent's recent social experiences and the resulting mental states and managing interpersonal challenges, particularly those involving separation or loss. The goal of this intervention is to improve the adolescent's ability to mentalize: to understand, acknowledge, and predict thoughts and feelings in oneself and others.

Mentalization-Based Therapy

Eligibility Criteria

• Age: 13 Years - 21 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Diagnosis of Bipolar Disorder I, Bipolar Disorder II, or Bipolar Disorder Not Otherwise Specified
• Living with or in close contact with at least one parent who is willing to participate
• Have had at least 1 week in the prior 3 months of significant suicidal ideation and/or at least one suicidal event in the 3 months prior to study intake.
• Willing to be treated pharmacologically by a psychiatrist in the UCLA Child and Adolescent Mood Disorders (CHAMP) clinic

You may not qualify if:

• Participants requiring immediate hospitalization
• Diagnosis of borderline personality disorder, schizophrenia, or schizoaffective disorder.
• Current substance dependence disorder

Sponsors & Collaborators

• University of California, Los Angeles: lead
• American Foundation for Suicide Prevention: collaborator

Study Sites (1)

University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

Related Publications (2)

• Miklowitz DJ, Taylor DO. Family-focused treatment of the suicidal bipolar patient. Bipolar Disord. 2006 Oct;8(5 Pt 2):640-51. doi: 10.1111/j.1399-5618.2006.00320.x.

  PMID: 17042836 BACKGROUND

• Rossouw TI, Fonagy P. Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2012 Dec;51(12):1304-1313.e3. doi: 10.1016/j.jaac.2012.09.018.

  PMID: 23200287 BACKGROUND

Related Links

• UCLA Child and Adolescent Mood Disorders Program

MeSH Terms

Conditions

Bipolar Disorder; Suicidal Ideation; Depression; Self-Injurious Behavior

Interventions

Mentalization-Based Therapy

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders; Suicide; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• David J Miklowitz, Ph.D.

  UCLA Department of Psychiatry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Psychiatry

Study Record Dates

• First Submitted: April 25, 2014
• First Posted: May 2, 2014
• Study Start: January 1, 2014
• Primary Completion: September 1, 2017
• Study Completion: September 1, 2018
• Last Updated: April 18, 2019

Record last verified: 2019-04

Locations

US (1)