Topical Infliximab in Autoimmune Eyes With Keratoprosthesis

You may not qualify if:

• Active or recurrent ocular or systemic infection
• Chest radiography, QuantiFERON-TB Gold or purified protein derivative (PPD) evidence of active or latent tuberculosis infection
• Indeterminate initial and repeat QuantiFERON-TB Gold results
• History of Bacille Calmette-Guerin (BCG) vaccination within twelve months of screening
• History of latent or active granulomatous infection, including histoplasmosis or coccidioidomycosis, prior to screening
• Chest radiograph within three months prior to the first administration of the study drug that shows an abnormality suggestive of a malignancy or current active infection, including tuberculosis.
• History of a nontuberculous mycobacterial infection or opportunistic infection (e.g. cytomegalovirus, pneumocystosis, aspergillosis) within six months prior to screening
• history of hepatitis B virus
• Methicillin resistant Staphylococcus aureus (MRSA) or vancomycin resistant enterococcus (VRE) infection
• Malignancy diagnosed in the last five years
• Demyelinating disease
• History or current diagnosis of diabetes mellitus (controlled and uncontrolled)
• Heart failure (New York Heart Association class III or IV)
• Pregnancy or breast-feeding
• Scheduled to receive a live vaccine at any time point during study participation
• +5 more criteria