The Effect of Exercises on Physiological Changes and Clinical Symptoms in Allergic Rhinitis Patients

NCT02123914 | Completed

• 1 other identifier: SPSC-2
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.Moderate exercise training decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
2. 2.Moderate exercise training combined with vitamin C supplementation decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
3. 3.Moderate exercise training combined with vitamin C supplementation has more beneficial effects than moderate exercise training alone for decreasing cytokine response and rhinitis symptoms in patients with allergic rhinitis

Conditions

Allergic Rhinitis

Keywords

Exercise training; Allergic rhinitis; Vitamin C; Cytokine; Rhinitis symptoms

Outcome Measures

Primary Outcomes (2)

• Changes from baseline in rhinitis symptoms

  Nasal symptoms will be assessed using a rhinitis symptom score questionnaire. The subjects will be asked to score symptoms of persistent allergic rhinitis; nasal congestion, itching, sneezing, and rhinorrhea before and after each exercise protocol. The score ranged from 0 to 3 points (0 = none, 1 = mild, 2 = moderate, 3 = severe).

  Baseline, week 8

• Changes from baseline in cytokine

  The cytokines IL-2, IL-4, and IL-13 in blood and nasal secretion will be determined by using the flow cytometry technique (Scavuzzo MC. et al., 2003). Data will be acquired using a flow cytometer (BD FACSCalibur Flow Cytometer, USA) and analyzed by FlowcytomixTM Pro software (eBioscience, USA.).

  baseline, week 8

Secondary Outcomes (4)

• Changes from baseline in pulmonary function

  Baseline, Week 8

• Changes from baseline in cardiorespiratory fitness (VO2max)

  Baseline, Week 8

• Changes from baseline in nasal blood flow

  Baseline, week 8

• Changes from baseline in peak nasal inspiratory flow

  Baseline, Week 8

Study Arms (2)

Aerobic exercise with Vit. C & Aerobic exercise

EXPERIMENTAL

Other: Aerobic exercise with Vit. C; Other: Aerobic exercise

exercise without vit. c supplement & no exercise

ACTIVE COMPARATOR

Other: Aerobic exercise with Vit. C; Other: No exercise

Interventions

Aerobic exercise with Vit. C OTHER

walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week combined with taking vitamin C supplemented daily with an oral dose of 2,000 mg 2 times/day for 8 weeks. Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid, Nasal peak flow measurement, Nasal blood flow measurement, Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.

Aerobic exercise with Vit. C & Aerobic exercise; exercise without vit. c supplement & no exercise

Aerobic exercise OTHER

walking - running on a treadmill at intensity of 65-70% HRR for 30 minutes per session three times a week for 8 weeks. Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid, Nasal peak flow measurement, Nasal blood flow measurement, Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.

Aerobic exercise with Vit. C & Aerobic exercise

No exercise OTHER

Sedentary control. Nasal challenge with house dust mites with the evaluation of cytokines in nasal lavage fluid, Nasal peak flow measurement, Nasal blood flow measurement, Exercise training regimen including VO2max measurment at baseline and at the end of the experiment.

exercise without vit. c supplement & no exercise

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may not qualify if:

• Subjects with known asthma, chronic rhinosinusitis, hypertension or cardiovascular diseases were excluded.

Sponsors & Collaborators

• Chulalongkorn University: lead

Study Sites (1)

Faculty of Sports Science, Chulalongkorn University

Patumwan, Bangkok, 10330, Thailand

Location

Related Publications (1)

• Klaewsongkram J, Ruxrungtham K, Wannakrairot P, Ruangvejvorachai P, Phanupak P. Eosinophil count in nasal mucosa is more suitable than the number of ICAM-1-positive nasal epithelial cells to evaluate the severity of house dust mite-sensitive allergic rhinitis: a clinical correlation study. Int Arch Allergy Immunol. 2003 Sep;132(1):68-75. doi: 10.1159/000073266.

  PMID: 14555860 BACKGROUND

MeSH Terms

Conditions

Rhinitis, Allergic

Interventions

Exercise; Ascorbic Acid

Condition Hierarchy (Ancestors)

Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates

Study Officials

• Daroonwan Suksom, Ph.D.

  Faculty of Sports Science, Chulalongkorn University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Faculty of Sports Science

Study Record Dates

• First Submitted: April 22, 2014
• First Posted: April 28, 2014
• Study Start: January 1, 2012
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: August 4, 2015

Record last verified: 2015-08

Locations

TH (1)