Hemodynamic Changes During One Lung Ventilation in Non-intubated Vedio-assisted Thoracoscopic Operations

NCT02123173 | Completed

• 1 other identifier: 201401037RINB
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

Non-intubated thoracoscopic surgery has been proved as an adequate alternative for management of many lung conditions such as pneumothorax , lung volume reduction, pulmonary metastasectomy, removal of lung nodules, segmentectomy and lobectomy. However, the hemodynamic changes during one lung ventilation have not been fully investigated. The goals of this study are to compare the changes of hemodynamics (including blood pressure, heart rate, cardiac output, pulse pressure variation, fluid responsiveness) during one lung ventilation between conventional intubated and non-intubated vedio-assisted thoracoscopic (VATS) operations.

Conditions

Lung Neoplasms

Keywords

one lung ventilation,; cardiac output; fluid responsiveness

Outcome Measures

Primary Outcomes (1)

• cardiac output after one lung ventilation

  record the stroke volume and cardiac output during two lung ventilation till 15 minutes after one lung ventilation

  10-15 minutes

Study Arms (2)

non-intubated

VATS, non-intubated

intubated

VATS, intubated

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients scheduled to receive video-assisted thoracoscopic (VATS) operations with one lung ventilation(OLV) Inclusion criteria: 1. age over 20 y/o, less than 70 y/o 2. scheduled to receive VATS operations with OLV Exclusion: 1. previous thoracic surgery 2. cardiac disease ( including arrhythmias, congestive heart failure, coronary cardiac disease, etc.) 3. pulmonary disease

You may qualify if:

• age over 20 y/o, less than 70 y/o
• scheduled to receive VATS operations with OLV

You may not qualify if:

• previous thoracic surgery
• cardiac disease ( including arrhythmias, congestive heart failure, coronary cardiac disease, etc.)
• pulmonary disease

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan, 100, Taiwan

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ya-Jung Cheng

  department of anesthesiology, national taiwan university hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2014
• First Posted: April 25, 2014
• Study Start: May 1, 2014
• Primary Completion: November 1, 2014
• Study Completion: December 1, 2014
• Last Updated: December 4, 2014

Record last verified: 2014-12

Locations

TW (1)