Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma
1 other identifier
interventional
40
1 country
1
Brief Summary
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2014
CompletedFirst Submitted
Initial submission to the registry
April 4, 2014
CompletedFirst Posted
Study publicly available on registry
April 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2015
CompletedNovember 18, 2014
November 1, 2014
1.3 years
April 4, 2014
November 15, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Asthma severity score
60 minute
Secondary Outcomes (1)
Length of stay in the hospital
within 2 weeks
Study Arms (2)
isotonic magnesium sulphate
EXPERIMENTAL2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) on three occasional at 20 minutes interval
50% magnesium sulphate
ACTIVE COMPARATORmagnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose
Interventions
2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) NB on three occasional at 20 minutes interval
magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose
Eligibility Criteria
You may qualify if:
- Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy
You may not qualify if:
- chronic lung disease
- history of adverse reaction form magnesium sulphate
- life threatening condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Queen Sirikit National Institute of Child Health
Bangkok, 10400, Thailand
Related Publications (1)
Powell CV, Kolamunnage-Dona R, Lowe J, Boland A, Petrou S, Doull I, Hood K, Williamson PR; MAGNETIC study group. MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children. Health Technol Assess. 2013 Oct;17(45):v-vi, 1-216. doi: 10.3310/hta17450.
PMID: 24144222RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Tassalapa Daengsuwan, Pediatrician
Queen Sirikit National Institute of Child Health
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- medical doctor
Study Record Dates
First Submitted
April 4, 2014
First Posted
April 11, 2014
Study Start
January 1, 2014
Primary Completion
May 1, 2015
Study Completion
May 1, 2015
Last Updated
November 18, 2014
Record last verified: 2014-11