Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU

NCT02111876 | Completed

• 2 other identifiers: CE 11-238LIgue Pulmonaire Genevoise
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not known in this population. This prospective cohort describes the clinical profile, predictors of readmission (followed over a year), and the prevalence of sleep-related breathing disorders (polysomnography in a stable clinical condition 3 months after ICU discharge) in patients treated for an episode of acute hypercapnic respiratory failure in the ICU.

Conditions

Acute Hypercapnic Respiratory Failure

Keywords

ICU, COPD, OHS, OSA, heart failure

Outcome Measures

Primary Outcomes (2)

• Sleep apnea syndrome

  Apnea-Hypopnea Index defined by polysomnography

  at 2 month after ICU discharge

• Sleep Hypoventilation

  defined by AASM 2012 criteria with transcutaneous PtCO2 monitoring

  at 2 month after ICU discharge

Secondary Outcomes (4)

• Lung physiology ( obstructive or restrictive lung disease)

  at week 2 after ICU discharge

• Inspiratory Muscle Strength

  at week 2 after ICU discharge

• Cardiac function

  at week 2 after ICU discharge

• Hospital and ICU readmission rate

  1 year follow-up after ICu discharge

Study Arms (1)

AHRF follow-up

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients surviving an episode of acute hypercapnic respiratory failure in the ICU

You may qualify if:

• \> 18 years Informed consent surviving an episode of acute hypercapnic respiratory failure

You may not qualify if:

• iatrogenic hypercpania pregnant woman

Sponsors & Collaborators

• Ligue Pulmonaire Genevoise: lead
• University Hospital, Geneva: collaborator

Study Sites (1)

Hôpitaux Universitaires de Genpve

Geneva, 1211, Switzerland

Location

Related Publications (2)

• Karege G, Zekry D, Allali G, Adler D, Marti C. Gait speed is associated with death or readmission among patients surviving acute hypercapnic respiratory failure. BMJ Open Respir Res. 2020 Jun;7(1):e000542. doi: 10.1136/bmjresp-2019-000542.

  PMID: 32561512 DERIVED

• Adler D, Pepin JL, Dupuis-Lozeron E, Espa-Cervena K, Merlet-Violet R, Muller H, Janssens JP, Brochard L. Comorbidities and Subgroups of Patients Surviving Severe Acute Hypercapnic Respiratory Failure in the Intensive Care Unit. Am J Respir Crit Care Med. 2017 Jul 15;196(2):200-207. doi: 10.1164/rccm.201608-1666OC.

  PMID: 27973930 DERIVED

MeSH Terms

Conditions

Respiratory Insufficiency; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Heart Failure

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Sleep Apnea Syndromes; Apnea; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Heart Diseases; Cardiovascular Diseases

Study Officials

• Adler E Adler, M.D.

  HUG

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2014
• First Posted: April 11, 2014
• Study Start: September 1, 2012
• Primary Completion: July 1, 2014
• Study Completion: July 1, 2014
• Last Updated: September 8, 2025

Record last verified: 2014-04

Locations

CH (1)