Strength and Balance in Gender- and Age-Matched Controls

NCT02110875 | Completed

• 1 other identifier: e9576
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to learn more about balance and strength in an elderly population (60 and older). Data will be compared between controls and the age/gender- matched PD participants in study "The Effects of vitamin D on Balance in Parkinson's disease" (OHSU IRB # 6482). Specifically a t-test will be used to compare total work and total power on leg extension and flexion, composite SOT score conditions 1-3 and 4-6, response strength and latency on MCT, and turn duration from the iMOBILITY between the two groups.

Conditions

Healthy Volunteers

Keywords

Healthy Volunteers

Outcome Measures

Primary Outcomes (1)

• Strength (BIODEX)

  The participant's strength will be evaluated using a machine that resembles a stationary exercise bike. They will have one leg and foot strapped onto the machine. Participants will then be asked to flex and extend their leg as quickly as possible five times. This will be repeated with the other leg.

  Visit 1

Secondary Outcomes (1)

• Balance (SOT)

  Visit 1

Study Arms (1)

CONTROLS

Age- and Gender-Matched Controls

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy Elderly (over 59 years old) without Parkinson's disease or Parkinsonism.

You may qualify if:

• Over the age of 59
• Gender and Age-Matched (within 3 years) of main protocol participants

You may not qualify if:

• Parkinson's disease diagnosis
• Significant cognitive deficits.
• Another neurological or orthopedic deficit that in the investigator's opinion would have a significant impact on gait and cognition (e.g. stroke, fracture).

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Health & Science University

Portland, Oregon, 97239, United States

Location

Related Publications (5)

• Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004 Jul;52(7):1121-9. doi: 10.1111/j.1532-5415.2004.52310.x.

  PMID: 15209650 BACKGROUND

• Horlings CG, van Engelen BG, Allum JH, Bloem BR. A weak balance: the contribution of muscle weakness to postural instability and falls. Nat Clin Pract Neurol. 2008 Sep;4(9):504-15. doi: 10.1038/ncpneuro0886.

  PMID: 18711425 BACKGROUND

• Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006 Sep;35 Suppl 2:ii37-ii41. doi: 10.1093/ageing/afl084.

  PMID: 16926202 BACKGROUND

• Inkster LM, Eng JJ, MacIntyre DL, Stoessl AJ. Leg muscle strength is reduced in Parkinson's disease and relates to the ability to rise from a chair. Mov Disord. 2003 Feb;18(2):157-62. doi: 10.1002/mds.10299.

  PMID: 12539208 BACKGROUND

• Allen NE, Canning CG, Sherrington C, Fung VS. Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease. Mov Disord. 2009 Jul 15;24(9):1344-51. doi: 10.1002/mds.22609.

  PMID: 19425085 BACKGROUND

Study Officials

• Amie L Peterson, MD

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 7, 2014
• First Posted: April 10, 2014
• Study Start: June 1, 2013
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2014
• Last Updated: October 20, 2014

Record last verified: 2014-10

Locations

US (1)