NCT02110836

Brief Summary

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for the ability to perform intense/prolonged endurance exercise. Therefore, nutritional strategies which can maximise the availability of glycogen in muscle and liver can benefit endurance exercise capacity. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. If glucose only is ingested during exercise, then the maximum rate at which can be absorbed from the intestine into the blood stream is \~1 g/min. However, if different sources of carbohydrate (fructose) are used, which are absorbed through a different pathway, absorption of carbohydrate can be up to \~1.8 g/min. With more carbohydrate available as a fuel, this translates into an improvement in performance. Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores during exercise. Therefore the aim of this study is to assess whether sucrose ingestion influences liver and muscle glycogen depletion during endurance exercise.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2014

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2014

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

April 3, 2014

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 10, 2014

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2014

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2015

Completed
Last Updated

August 7, 2015

Status Verified

August 1, 2015

Enrollment Period

5 months

First QC Date

April 3, 2014

Last Update Submit

August 4, 2015

Conditions

Liver and Muscle Glycogen Use During Exercise.

Outcome Measures

Primary Outcomes (1)

  • Change in liver glycogen concentration

    The change in liver glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy.

    3 hours

Secondary Outcomes (6)

  • Plasma glucose concentration.

    3 hours

  • Plasma lactate concentration

    3 hours

  • Plasma non-esterified fatty acid concentration

    3 hours

  • Indirect calorimetry

    3 hours

  • Muscle glycogen concentration

    3 hours

  • +1 more secondary outcomes

Study Arms (2)

Glucose ingestion

ACTIVE COMPARATOR

Glucose ingestion during exercise at a rate of 1.8 g/min.

Dietary Supplement: Glucose ingestion

Sucrose ingestion

EXPERIMENTAL

Sucrose ingestion during exercise at a rate of 1.8 g/min.

Dietary Supplement: Sucrose ingestion

Interventions

Glucose ingestionDIETARY_SUPPLEMENT

Glucose ingestion during exercise at 1.8 g/min

Glucose ingestion
Sucrose ingestionDIETARY_SUPPLEMENT

Sucrose ingestion during exercise at 1.8 g/min

Sucrose ingestion

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy
  • Male
  • years of age
  • Endurance trained cyclist/triathlete
  • VO2 max ≥ 50 ml/kg/min

You may not qualify if:

  • Use of medication
  • Smoking
  • Metabolic disorders

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Location

Related Publications (1)

  • Gonzalez JT, Fuchs CJ, Smith FE, Thelwall PE, Taylor R, Stevenson EJ, Trenell MI, Cermak NM, van Loon LJ. Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E1032-9. doi: 10.1152/ajpendo.00376.2015. Epub 2015 Oct 20.

    PMID: 26487008DERIVED

Study Officials

  • Luc van Loon, PhD

    Maastricht University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Research Fellow

Study Record Dates

First Submitted

April 3, 2014

First Posted

April 10, 2014

Study Start

April 1, 2014

Primary Completion

September 1, 2014

Study Completion

April 1, 2015

Last Updated

August 7, 2015

Record last verified: 2015-08

Locations

GB(1)