Sponsor study identifier
interventional
14
1 country
1
Study Start
April 2014
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2014
Actual (reported)Study Completion
April 2015
Actual (reported)Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for the ability to perform intense/prolonged endurance exercise. Therefore, nutritional strategies which can maximise the availability of glycogen in muscle and liver can benefit endurance exercise capacity. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. If glucose only is ingested during exercise, then the maximum rate at which can be absorbed from the intestine into the blood stream is \~1 g/min. However, if different sources of carbohydrate (fructose) are used, which are absorbed through a different pathway, absorption of carbohydrate can be up to \~1.8 g/min. With more carbohydrate available as a fuel, this translates into an improvement in performance. Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores during exercise. Therefore the aim of this study is to assess whether sucrose ingestion influences liver and muscle glycogen depletion during endurance exercise.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2015
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2014
Date type not reportedThis date has not been verified as actual or estimated.
April 3, 2014
Actual (reported)April 10, 2014
Actual (reported)September 2014
Actual (reported)April 2015
Actual (reported)Change in liver glycogen concentration
The change in liver glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy.
3 hours
Plasma glucose concentration.
3 hours
Plasma lactate concentration
3 hours
Plasma non-esterified fatty acid concentration
3 hours
Indirect calorimetry
3 hours
Muscle glycogen concentration
3 hours
Glucose ingestion during exercise at a rate of 1.8 g/min.
Sucrose ingestion during exercise at a rate of 1.8 g/min.
Glucose ingestion during exercise at 1.8 g/min
Sucrose ingestion during exercise at 1.8 g/min
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Northumbria University
Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom
Gonzalez JT, Fuchs CJ, Smith FE, Thelwall PE, Taylor R, Stevenson EJ, Trenell MI, Cermak NM, van Loon LJ. Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E1032-9. doi: 10.1152/ajpendo.00376.2015. Epub 2015 Oct 20.
Luc van Loon, PhD
Maastricht University
14 participants (actual enrollment reported by the registry).
First Submitted
April 3, 2014
First Posted
April 10, 2014
Study Start
April 2014
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Primary Completion
September 2014
Actual (reported)Study Completion
April 2015
Actual (reported)Last Updated
August 7, 2015
Record last verified: 2015-08
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Source: ClinicalTrials.gov.
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