Modulation of Visual-Spatial Learning in Healthy Young Adults by tDCS

NCT02110407 | Completed

• 1 other identifier: LOCATO-YA-tDCS
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy young adults and to examine the underlying neuronal mechanism.

Conditions

Healthy Young Adults

Keywords

healthy young adults; tDCS; LOCATO task; visual-spatial learning

Outcome Measures

Primary Outcomes (1)

• performance in LOCATO task (visual-spatial learning and memory) after a combination of intensive visual-spatial training and tDCS

  Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to improvement of visual-spatial learning and memory measured by the performance in LOCATO task after end of a 3 day period of training compared to sham stimulation.

  immediately after end of a 3 day period of training in tDCS condition vs sham condition

Secondary Outcomes (6)

• long term effects

  after 1 month vs baseline

• functional changes: Connectivity

  after end of 3-day cognitive training vs baseline

• cortical excitability

  at baseline

• Quality of Life

  after 1 month vs baseline

• memory

  immediately after end of 3-day of cognitive training, after 1 month vs. baseline

Study Arms (2)

training + sham stimulation

SHAM COMPARATOR

Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation

Device: tDCS; Behavioral: training

training + tDCS

EXPERIMENTAL

Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS)

Device: tDCS; Behavioral: training

Interventions

tDCS DEVICE

transcranial direct current stimulation (tDCS)

training + sham stimulation; training + tDCS

training BEHAVIORAL

intensive training of visual-spatial abilities (in LOCATO task)

training + sham stimulation; training + tDCS

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• right handednesss
• unobtrusive neuropsychological screening
• age: 18-35 years

You may not qualify if:

• severe internal or psychiatric disease
• epilepsy
• other severe neurological disease, e.g. previous major stroke, brain tumor
• DMS-IV manifest dementia
• contraindication for MRT (claustrophobia, metallic implants, tattoos)

Sponsors & Collaborators

• Charite University, Berlin, Germany: lead

Study Sites (1)

Charite Universitätsmedizin Berlin

Berlin, 10117, Germany

Location

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Agnes Flöel, Prof. Dr.

  Charite University, Berlin, Germany

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: February 13, 2014
• First Posted: April 10, 2014
• Study Start: March 1, 2014
• Primary Completion: January 1, 2017
• Study Completion: May 1, 2017
• Last Updated: July 27, 2017

Record last verified: 2017-07

Locations

DE (1)