NCT02105844|Active Not Recruiting
Swiss Atrial Fibrillation Cohort Study
SWISS-AF
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SWISS-AF
Sponsor study identifier
observational
2,415
1 country
1
Study Start
March 2014
Actual (reported)Primary Completion
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged \>65 years will be included and followed on a yearly basis. Yearly clinical examinations include a detailed questionnaire on personal characteristics, a resting electrocardiogram, neurocognitive function tests and questionnaires on disability and quality of life. Blood sampling and brain magnetic resonance imaging are scheduled at baseline and after 2 years of follow-up. The main study aims of this long term prospective study are to increase our knowledge on structural brain damage and its changes over time in patients with atrial fibrillation, to gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with atrial fibrillation and to evaluate the interrelationships of structural and functional brain damage in this population.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2014
Actual (reported)March 28, 2014
Actual (reported)April 7, 2014
Actual (reported)March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Stroke or systemic embolism
2018 (after an average of 2.5 years of follow-up)
Hospitalization for heart failure
2018 (after an average of 2.5 years of follow-up)
Cohort Study on patients with atrial fibrillation in Switzerland
Consecutive patients with atrial fibrillation
University Hospital
Basel, Canton of Basel-City, 4031, Switzerland
Krisai P, Mutti M, Aeschbacher S, Coslovsky M, Reichlin T, Rodondi N, Ammann P, Moschovitis G, Rigamonti E, Conte G, Haller ML, Stoecklin A, Bonati LH, Osswald S, Conen D, Mahfoud F, Kuhne M. Impact of differences in kidney function estimation by creatinine compared to cystatin C on clinical outcomes in patients with atrial fibrillation. Eur Heart J Open. 2026 Sep 22;6(5):oeag145. doi: 10.1093/ehjopen/oeag145. eCollection 2026 Sep.
Hennings E, Aeschbacher S, Neuschwander P, Coslovsky M, Istampoulouoglou I, Leuppi-Taegtmeyer A, Paladini RE, Strobel L, Reichlin T, Rodondi N, Beer JH, Conte G, Auricchio A, Moschovitis G, Di Valentino M, Adam L, De Perna ML, Bonati LH, Mahfoud F, Krisai P, Zuern CS, Conen D, Sticherling C, Osswald S, Kuhne M; Swiss-AF Investigators17. Drug-drug interactions of NOACs with comedication: Prevalence and implications for adverse events in patients with atrial fibrillation. Heart Rhythm O2. 2026 Jun 18;7(9):1680-1690. doi: 10.1016/j.hroo.2026.06.007. eCollection 2026 Sep.
samples with DNA
Stefan Osswald, MD, Prof.
University Hospital, Basel, Switzerland
Michael Kuehne, MD, PD, exec. MBA
University Hospital, Basel, Switzerland
David Conen, MD MPH
McMaster University, Population Health Research Institute, Hamilton, Canada
2,415 participants (actual enrollment reported by the registry).
First Submitted
March 28, 2014
First Posted
April 7, 2014
Study Start
March 2014
Actual (reported)SmartWATCHes for Detection of Atrial Fibrillation
Contact the study team to confirm eligibility.
Koechlin M, Paladini RE, Aeschbacher S, Zuern CS, Strebel I, Coslovsky M, Liskij M, Kerler R, Krisai P, Bonati LH, Conen D, Mahfoud F, Osswald S, Kuhne M, Kaufmann BA. Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation. Front Cardiovasc Med. 2026 Jul 1;13:1878401. doi: 10.3389/fcvm.2026.1878401. eCollection 2026.
Bhend K, Paladini R, Aeschbacher S, Hennings E, Coslovsky M, Krisai P, Rodondi N, Beer J, Auricchio A, Moschovitis G, Storrer N, Chocano-Bedoya PO, Rigamonti E, Sinnecker T, Conen D, Osswald S, Bonati L, Kuhne M. Brain lesions and cognitive decline in patients with atrial fibrillation: a prospective multicentre cohort study. Swiss Med Wkly. 2026 Jan 9;156:4059. doi: 10.57187/s.4059.
Kupper BC, Reiner MF, Werlen L, Aeschbacher S, Lee P, Allemann MS, Moschovitis G, Luscher T, Camici GG, Rodondi N, Adam L, Meyre PB, Bonati LH, Sinnecker T, Kuhne M, Osswald S, Conen D, Beer JH; Swiss-AF Investigators. Plasma beta-Thromboglobulin Is Inversely Associated With Cerebral Microbleeds in Atrial Fibrillation. Stroke. 2025 Dec;56(12):3414-3423. doi: 10.1161/STROKEAHA.124.049972. Epub 2025 Sep 17.
Iten V, Herber E, Coslovsky M, Hennings E, Paladini RE, Reichlin T, Rodondi N, Muller AS, Stauber A, Beer JH, Brenner R, Conte G, Kobza R, Di Valentino M, Bedoya PC, Moradi F, Sinnecker T, Bonati LH, Kuhne M, Osswald S, Conen D, Aeschbacher S, Zuern CS; Swiss-AF and Beat-AF Investigators. Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation. BMC Med. 2024 Dec 18;22(1):593. doi: 10.1186/s12916-024-03817-x.
Barbagallo M, Springer A, Vanetta C, Allemann M, Lee P, Saeedi S, Aeschbacher S, Luciani M, Bonati LH, Moschovitis G, Scheu V, Rutishauser J, Kobza R, Di Valentino M, Meyre PB, Rodondi N, Conen D, Kuhne M, Osswald S, Beer JH; Swiss-AF investigators. Coffee Consumption Correlates With Better Cognitive Performance in Patients With a High Incidence for Stroke. J Am Heart Assoc. 2025 Jan 7;14(1):e034365. doi: 10.1161/JAHA.124.034365. Epub 2024 Dec 14.
Carmine D, Aeschbacher S, Coslovsky M, Hennings E, Paladini RE, Peter R, Burger M, Reichlin T, Rodondi N, Muller AS, Ammann P, Conte G, Auricchio A, Moschovitis G, Bardoczi JB, Stauber A, De Perna ML, Zuern CS, Sinnecker T, Badertscher P, Sticherling C, Bonati LH, Conen D, Krisai P, Osswald S, Kuhne M. Blood pressure, brain lesions and cognitive decline in patients with atrial fibrillation. Front Cardiovasc Med. 2024 Sep 3;11:1449506. doi: 10.3389/fcvm.2024.1449506. eCollection 2024.
Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, Lee P, Rodondi N, Moutzouri E, Bonati L, Reichlin T, Moschovitis G, Rutishauser J, Kuhne M, Osswald S, Conen D, Beer JH. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024 Jan 5;16(2):178. doi: 10.3390/nu16020178.
Stauber A, Muller A, Rommers N, Aeschbacher S, Rodondi N, Bonati LH, Beer JH, Jeger RV, Kurz DJ, Liedtke C, Ammann P, Di Valentino M, Chocano P, Kobza R, Kuhne M, Conen D, Osswald S, Bernheim AM. Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF). Swiss Med Wkly. 2023 Aug 23;153:40109. doi: 10.57187/smw.2023.40109.
Hennings E, Blum S, Aeschbacher S, Coslovsky M, Knecht S, Eken C, Lischer M, Paladini RE, Krisai P, Reichlin T, Rodondi N, Beer JH, Ammann P, Conte G, De Perna ML, Kobza R, Blum MR, Bossard M, Kastner P, Ziegler A, Muller C, Bonati LH, Pfister O, Zuern CS, Conen D, Kuhne M, Osswald S; Swiss-AF Investigators. Bone Morphogenetic Protein 10-A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation. J Am Heart Assoc. 2023 Mar 21;12(6):e028255. doi: 10.1161/JAHA.122.028255. Epub 2023 Mar 16.
Luciani M, Muller D, Vanetta C, Diteepeng T, von Eckardstein A, Aeschbacher S, Rodondi N, Moschovitis G, Reichlin T, Sinnecker T, Wuerfel J, Bonati LH, Saeedi Saravi SS, Chocano-Bedoya P, Coslovsky M, Camici GG, Luscher TF, Kuehne M, Osswald S, Conen D, Beer JH; SWISS-AF Investigators. Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation. Heart. 2023 Feb 14;109(5):396-404. doi: 10.1136/heartjnl-2022-321300.
Zwimpfer L, Aeschbacher S, Krisai P, Coslovsky M, Springer A, Paladini RE, Girod M, Hufschmid J, Knecht S, Badertscher P, Beer JH, Bonati LH, Zuern CS, Roten L, Reichlin T, Sticherling C, Conen D, Osswald S, Kuhne M. Neurocognitive function in patients with atrial fibrillation undergoing pulmonary vein isolation. Front Cardiovasc Med. 2022 Nov 25;9:1000799. doi: 10.3389/fcvm.2022.1000799. eCollection 2022.
Girod M, Coslovsky M, Aeschbacher S, Sticherling C, Reichlin T, Roten L, Rodondi N, Ammann P, Auricchio A, Moschovitis G, Kobza R, Badertscher P, Knecht S, Krisai P, Marugg A, Aebersold H, Hennings E, Serra-Burriel M, Schwenkglenks M, Zuern CS, Bonati LH, Conen D, Osswald S, Kuhne M. Association of pulmonary vein isolation and major cardiovascular events in patients with atrial fibrillation. Clin Res Cardiol. 2022 Sep;111(9):1048-1056. doi: 10.1007/s00392-022-02015-0. Epub 2022 Apr 11.
Rivolta MW, Mainardi LT, Laureanti R, Sassi R, Kuhne M, Rodondi N, Conte G, Moschovitis G, Schlageter V, Aeschbacher S, Conen D, Reichlin T, Roten L, Osswald S, Zuern CS, Auricchio A, Corino VDA. Association between ventricular repolarization parameters and cardiovascular death in patients of the SWISS-AF cohort. Int J Cardiol. 2022 Jun 1;356:53-59. doi: 10.1016/j.ijcard.2022.03.009. Epub 2022 Mar 9.
Kuhne M, Krisai P, Coslovsky M, Rodondi N, Muller A, Beer JH, Ammann P, Auricchio A, Moschovitis G, Hayoz D, Kobza R, Shah D, Stephan FP, Schlapfer J, Di Valentino M, Aeschbacher S, Ehret G, Eken C, Monsch A, Roten L, Schwenkglenks M, Springer A, Sticherling C, Reichlin T, Zuern CS, Meyre PB, Blum S, Sinnecker T, Wurfel J, Bonati LH, Conen D, Osswald S; Swiss-AF Investigators. Silent brain infarcts impact on cognitive function in atrial fibrillation. Eur Heart J. 2022 Jun 6;43(22):2127-2135. doi: 10.1093/eurheartj/ehac020.
Bano A, Rodondi N, Beer JH, Moschovitis G, Kobza R, Aeschbacher S, Baretella O, Muka T, Stettler C, Franco OH, Conte G, Sticherling C, Zuern CS, Conen D, Kuhne M, Osswald S, Roten L, Reichlin T; of the Swiss-Investigators. Association of Diabetes With Atrial Fibrillation Phenotype and Cardiac and Neurological Comorbidities: Insights From the Swiss-AF Study. J Am Heart Assoc. 2021 Nov 16;10(22):e021800. doi: 10.1161/JAHA.121.021800. Epub 2021 Nov 10.
Hammerle P, Aeschbacher S, Springer A, Eken C, Coslovsky M, Dutilh G, Moschovitis G, Rodondi N, Chocano P, Conen D, Osswald S, Kuhne M, Zuern CS. Cardiac autonomic function and cognitive performance in patients with atrial fibrillation. Clin Res Cardiol. 2022 Jan;111(1):60-69. doi: 10.1007/s00392-021-01900-4. Epub 2021 Jun 22.
Hammerle P, Eick C, Poli S, Blum S, Schlageter V, Bauer A, Rizas KD, Eken C, Coslovsky M, Aeschbacher S, Krisai P, Meyre P, Wuerfel J, Sinnecker T, Vesin JM, Beer JH, Moschovitis G, Bonati LH, Sticherling C, Conen D, Osswald S, Kuhne M, Zuern CS. Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation. Front Cardiovasc Med. 2021 May 21;8:684461. doi: 10.3389/fcvm.2021.684461. eCollection 2021.
Benz AP, Aeschbacher S, Krisai P, Moschovitis G, Blum S, Meyre P, Blum MR, Rodondi N, Di Valentino M, Kobza R, De Perna ML, Bonati LH, Beer JH, Kuhne M, Osswald S, Conen D; BEAT-AF, Swiss-AF Investigators. Biomarkers of Inflammation and Risk of Hospitalization for Heart Failure in Patients With Atrial Fibrillation. J Am Heart Assoc. 2021 Apr 20;10(8):e019168. doi: 10.1161/JAHA.120.019168. Epub 2021 Apr 10.
Reddiess P, Aeschbacher S, Meyre P, Coslovsky M, Kuhne M, Rodondi N, Baretella O, Beer JH, Kobza R, Moschovitis G, Di Valentino M, Muller C, Steiner F, Bonati LH, Sticherling C, Osswald S, Conen D; BEAT-AF and Swiss-AF investigators. Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation. CMAJ. 2021 Jan 25;193(4):E117-E123. doi: 10.1503/cmaj.200778.
Steiner F, Meyre PB, Aeschbacher S, Coslovsky M, Sinnecker T, Blum MR, Rodondi N, Cereda CW, di Valentino M, Wenger F, Cussigh A, Krisai P, Roten L, Reichlin T, Conen D, Osswald S, Bonati LH, Kuhne M; Swiss-AF Investigators. Association of the CHA2D(S2)-VASc Score and Its Components With Overt and Silent Ischemic Brain Lesions in Patients With Atrial Fibrillation. Front Neurol. 2021 Jan 12;11:609234. doi: 10.3389/fneur.2020.609234. eCollection 2020.
Aeschbacher S, Blum S, Meyre PB, Coslovsky M, Vischer AS, Sinnecker T, Rodondi N, Beer JH, Moschovitis G, Moutzouri E, Hunkeler C, Burkard T, Eken C, Roten L, Zuern CS, Sticherling C, Wuerfel J, Bonati LH, Conen D, Osswald S, Kuhne M; Swiss-AF Investigators*. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation. Hypertension. 2021 Feb;77(2):662-671. doi: 10.1161/HYPERTENSIONAHA.120.16025. Epub 2020 Dec 28.
Meyre PB, Springer A, Aeschbacher S, Blum S, Rodondi N, Beer JH, Di Valentino M, Ammann P, Blum M, Mathys R, Meyer-Zurn C, Bonati LH, Sticherling C, Schwenkglenks M, Kuhne M, Conen D, Osswald S; Swiss-AF investigators. Association of psychosocial factors with all-cause hospitalizations in patients with atrial fibrillation. Clin Cardiol. 2021 Jan;44(1):51-57. doi: 10.1002/clc.23503. Epub 2020 Nov 10.
Hammerle P, Eick C, Blum S, Schlageter V, Bauer A, Rizas KD, Eken C, Coslovsky M, Aeschbacher S, Krisai P, Meyre P, Vesin JM, Rodondi N, Moutzouri E, Beer J, Moschovitis G, Kobza R, Di Valentino M, Corino VDA, Laureanti R, Mainardi L, Bonati LH, Sticherling C, Conen D, Osswald S, Kuhne M, Zuern CS; Swiss-AF Study Investigators. Heart Rate Variability Triangular Index as a Predictor of Cardiovascular Mortality in Patients With Atrial Fibrillation. J Am Heart Assoc. 2020 Aug 4;9(15):e016075. doi: 10.1161/JAHA.120.016075. Epub 2020 Jul 28.
Gugganig R, Aeschbacher S, Leong DP, Meyre P, Blum S, Coslovsky M, Beer JH, Moschovitis G, Muller D, Anker D, Rodondi N, Stempfel S, Mueller C, Meyer-Zurn C, Kuhne M, Conen D, Osswald S; Swiss-AF Investigators. Frailty to predict unplanned hospitalization, stroke, bleeding, and death in atrial fibrillation. Eur Heart J Qual Care Clin Outcomes. 2021 Jan 25;7(1):42-51. doi: 10.1093/ehjqcco/qcaa002.
Primary Completion
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
July 9, 2025
Record last verified: 2025-07
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