Determination of Muscle Strength in Parkinsonian Patients Through the Use of an Isokinetic Dynamometer

NCT02101528 | Completed DMC

• 1 other identifier: CybexPD001
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Decreased muscle strength has been reported to be a factor contributing to increased incidences of falling in the elderly patients causing fractures, joint dislocations, severe soft tissue lesions and head trauma. Parkinson's Disease (PD) patients often complain of weakness and it has been reported that they have reduced muscle strength, decreased rate of force development, impaired ability to maintain constant force, and increased muscle coactivation during balance perturbation tasks. The specific cause of this weakness is not known, and in this study the investigators have analyzed and measured isokinetic muscle strength in PD patients to clarify this issue. The investigators have compared the data obtained with those of age-matched controls.

Conditions

Parkinson's Disease

Keywords

Strength in PD patients; Isokinetic muscle strength

Outcome Measures

Primary Outcomes (1)

• Isokinetic strength

  Laboratory measurements of isokinetic strength

  One month

Secondary Outcomes (1)

• Muscle functionality

  One month

Study Arms (2)

PD Patients

PD patients with a diagnosis of "clinically probable" idiopathic PD in Hoehn-Yahr stage 2-3, with the ability to walk without any assistance, with mini-mental state examination score ≥26, without any relevant comorbidity or vestibular/visual dysfunctions limiting locomotion or balance.

Controls

age and sex matched healthy volunteers

Eligibility Criteria

• Age: 55 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with PD in stage 2-3 of Hoen\&Yahr according to the United Kingdom Brain Bank criteria. Healthy Volunteers

You may qualify if:

• PD in stage 2-3 of Hoen\&Yahr according to the United Kingdom Brain Bank criteria.

You may not qualify if:

• Atypical parkinsonisms
• PD patients with relevant orthopedic
• Rheumatic and muscular conditions

Sponsors & Collaborators

• Ospedale Generale Di Zona Moriggia-Pelascini: lead

Study Sites (1)

Fondazione Salvatore Maugeri

Montescano, Pavia, 27100, Italy

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Giuseppe Frazzitta, MD

  Ospedale Generale di Zona "Moriggia-Pelascini", Gravedona ed Uniti (CO), Italy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2014
• First Posted: April 2, 2014
• Study Start: January 1, 2013
• Primary Completion: December 1, 2013
• Study Completion: March 1, 2014
• Last Updated: April 2, 2014

Record last verified: 2014-03

Locations

IT (1)