Knee Pain Phenotypes in the Community Study

NCT02098070 | Unknown DMC

• 1 other identifier: 14018
• Study Type: observational
• Target: 40,000
• Locations: 1 country
• Sites: 1

Brief Summary

The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over. It will also identify characteristics such as structural changes of osteoarthritis of the knee as well as physiological parameters and blood and urine biomarkers.

Conditions

Knee Osteoarthritis

Keywords

Knee Pain; Community Study; Knee Osteoarthritis; Risk Factors

Outcome Measures

Primary Outcomes (1)

• Knee Pain Phenotypes

  The prevalence of the different knee pain phenotypes, provided by specific pain questionnaires. This will include the Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP), the Pain Catastrophizing Scale (PCS) and the PainDetect (for neuropathic pain).

  up to 12 months

Secondary Outcomes (1)

• Other Risk Factors

  up to 12 months

Study Arms (2)

Knee Pain Population

Participants who have responded to the questionnaire with self-reported pain.

Non-Knee Pain Population

Participants who have responded to the questionnaire, no self-reported pain.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Community-derived sample

You may qualify if:

• Aged 40 years and over

You may not qualify if:

• Inability to give informed consent
• Terminal or mental illness
• Pregnant women

Sponsors & Collaborators

• University of Nottingham: lead
• Arthritis Research UK: collaborator

Study Sites (1)

Academic Rheumatology

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

Location

Related Publications (4)

• Swain S, Fernandes GS, Sarmanova A, Valdes AM, Walsh DA, Coupland C, Doherty M, Zhang W. Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatol Adv Pract. 2022 Jun 15;6(2):rkac049. doi: 10.1093/rap/rkac049. eCollection 2022.

  PMID: 35784017 DERIVED

• Fernandes GS, Parekh SM, Moses J, Fuller CW, Scammell B, Batt ME, Zhang W, Doherty M. Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case-control study. BMJ Open. 2019 Sep 8;9(9):e030056. doi: 10.1136/bmjopen-2019-030056.

  PMID: 31501119 DERIVED

• Fernandes GS, Valdes AM, Walsh DA, Zhang W, Doherty M. Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample. Arthritis Res Ther. 2018 Sep 27;20(1):215. doi: 10.1186/s13075-018-1717-6.

  PMID: 30261907 DERIVED

• Fernandes GS, Sarmanova A, Warner S, Harvey H, Akin-Akinyosoye K, Richardson H, Frowd N, Marshall L, Stocks J, Hall M, Valdes AM, Walsh D, Zhang W, Doherty M. Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskelet Disord. 2017 Sep 21;18(1):404. doi: 10.1186/s12891-017-1761-4.

  PMID: 28934932 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Whole Blood Urine

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Michael Doherty, MD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 14, 2014
• First Posted: March 27, 2014
• Study Start: September 1, 2014
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: August 24, 2017

Record last verified: 2017-08

Locations

GB (1)