Knee Osteoarthritis Risk in Retired Professional Footballers

NCT02098044 | Unknown DMC

• 1 other identifier: 13130
• Study Type: observational
• Target: 1,300
• Locations: 1 country
• Sites: 1

Brief Summary

The OA and Football Study is an epidemiological study designed to establish the prevalence of knee osteoarthritis in retired professional footballers. The study will also identify the key risk factors associated with knee osteoarthritis. The study is comprised of three phases: Phase I involves the dissemination of a questionnaire (demographic details, players history, injury and surgery and other known risk factors of OA), Phase II is a radiographic study that involves x-rays in a sample of footballers both with and without knee pain and Phase III is a case control study which will compared retired professional footballers with age-matched controls recruited from the general population in the East Midlands region.

Conditions

Osteoarthritis of the Knee

Keywords

knee osteoarthritis; epidemiology; risk factors; prevalence; professional football

Outcome Measures

Primary Outcomes (1)

• Self Reported Knee Pain

  Questionnaire data with regards to acute knee pain, type of pain, duration of pain and knee injury and knee surgery history.

  up to 12 months

Secondary Outcomes (1)

• Radiographic Knee OA changes

  up to 12 months

Study Arms (2)

Professional footballers

Retired professional footballers

Control Population

members of the general public recruited from the east midlands region

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Retired footballers will be recruited from a database of retired professional footballers. (cases) The members of the general public will be recruited from the general population in the East Midlands region. (controls)

You may qualify if:

• All current or retired professional male footballers (Registered with the Professional Footballer Association (age range 40 -80)
• Phase II
• Professional footballers both with and without a history of knee pain knee OA or knee surgical history
• No contraindications of the affected joint such as gout or rheumatoid arthritis
• Willingness to participate in a clinical assessment of the knee and provision of blood samples.
• Phase III
• Over the age of 40 (age range 40 - 80)
• Both with and without a history of knee pain over at least the last 1 year
• No history of significant trauma, injury or surgery to the lower limb
• American College of Rheumatology (ACR) classification of OA based on physical examination and clinical presentation: Pain in the knee and three of the following; over the age of 50, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement and no palpable warmth of synovium.
• Phase I

You may not qualify if:

• Not a registered professional footballer (current or past)
• Inaccurate information (discrepancy with questionnaire information compared to other football records. This will be verified by the co-investigator, Dr Fernandes and Mr Sanjay Parekh)
• Incomplete questionnaire or duplicate questionnaire.
• Phase II
• Not a registered professional footballer
• No written informed consent to participate
• Phase III
• Aged 39 and under
• Comorbidities such as rheumatoid arthritis, gout, osteoporosis
• History of injury, trauma or surgery to the lower limb.

Sponsors & Collaborators

• University of Nottingham: lead
• Arthritis Research UK: collaborator
• Federation Internationale de Football Association: collaborator
• SPIRE Hospitals: collaborator
• Football Association (UK): collaborator
• Professional Football Association (UK): collaborator

Study Sites (1)

Academic Rheumatology

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

Location

Related Publications (3)

• Drawer S, Fuller CW. Evaluating the level of injury in English professional football using a risk based assessment process. Br J Sports Med. 2002 Dec;36(6):446-51. doi: 10.1136/bjsm.36.6.446.

  PMID: 12453840 BACKGROUND

• Zhang W, McWilliams DF, Ingham SL, Doherty SA, Muthuri S, Muir KR, Doherty M. Nottingham knee osteoarthritis risk prediction models. Ann Rheum Dis. 2011 Sep;70(9):1599-604. doi: 10.1136/ard.2011.149807. Epub 2011 May 25.

  PMID: 21613308 BACKGROUND

• Fernandes GS, Parekh SM, Moses J, Fuller CW, Scammell B, Batt ME, Zhang W, Doherty M. Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case-control study. BMJ Open. 2019 Sep 8;9(9):e030056. doi: 10.1136/bmjopen-2019-030056.

  PMID: 31501119 DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Michael Doherty, MD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 14, 2014
• First Posted: March 27, 2014
• Study Start: November 1, 2014
• Primary Completion: January 1, 2016
• Study Completion: December 1, 2018
• Last Updated: May 24, 2018

Record last verified: 2018-05

Locations

GB (1)