Improving the Nutrition Status of Infants in South-Western Uganda

NCT02098031 | Completed

• 1 other identifier: 100
• Study Type: interventional
• Target: 511
• Locations: 1 country
• Sites: 1

Brief Summary

Undernutrition and growth restriction due to poor diet and inadequate nutrient intake continues to be a global challenge, particularly in the developing countries including Uganda. The etiology of inadequate nutrient supply to infants may relate to lack of resources or knowledge or a combination of both. Poor nutrient intake and impaired growth may affect brain and cognitive development. This study aims to evaluate nutrient intake, growth and cognitive function among children between 6 and 36 months living in the fertile Kabale and Kisoro region in south-western Uganda. The investigators hypothesize that nutrition education to mothers can bring about improved dietary intake and nutritional status among children aged 6-36 months. A follow-up study was conducted during the period January - July 2022.

Conditions

Infant Malnutrition; Nutrition Knowledge; Growth; Cognitive Development

Keywords

Child Nutrition Sciences; Growth and Development; Developing Countries

Outcome Measures

Primary Outcomes (1)

• Change in the prevalence of stunting (<-2 SD of the WHO, 2006 growth reference standards)

  The investigators will measure the change in stunting between the three indicated time points.

  6-8, 12-16, 20-24 (main outcome time point), 36 months, 7-10 years

Secondary Outcomes (13)

• Change in mean weight-for-age z-score

  6-8, 12-16 and 20-24, 36 months, 7-10 years

• Change in mean weight-for-height z-score

  6-8, 12-16, 20-24, 36 months, 7-10 years

• Change in mean Mid Upper Arm Circumference (MUAC) z-score

  6-8, 12-16, 20-24, 36 months, 7-10 years

• Change in mean diet diversification score (DDS)

  6-8, 12-16, 20-24, 36 months

• Change in Ages and Stages Questionnaire Scores (AQS)

  6-8, 12-16, 20-24, 36 months

Study Arms (2)

control

NO INTERVENTION

intervention

EXPERIMENTAL

Nutritional intervention (nutrition education)

Other: Improving nutrition knowledge among mothers

Interventions

Improving nutrition knowledge among mothers OTHER

intervention

Eligibility Criteria

• Age: 6 Months+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• A lead caretaker with a 6-8 months infant (child/lead caretaker pair) who will have given consent to participate in the study. If there is more than one child of the age in the household, the younger one will be taken as the index/study child.

You may not qualify if:

• Is older than 8 months at baseline
• Congenital malformations or physical handicap that may influence growth or interfere with taking of anthropometric measurements
• Disability that will influence nutrient intake
• Been diagnosed with mental or brain illness as evidenced by mother or health worker.
• If the family that is likely to emigrate during the study period

Sponsors & Collaborators

• University of Oslo: lead
• Kyambogo University: collaborator

Study Sites (1)

Kyambogo University

Kampala, Uganda

Location

Related Publications (5)

• Atukunda P, Ngari M, Chen X, Westerberg AC, Iversen PO, Muhoozi G. Longitudinal assessments of child growth: A six-year follow-up of a cluster-randomized maternal education trial. Clin Nutr. 2021 Sep;40(9):5106-5113. doi: 10.1016/j.clnu.2021.08.007. Epub 2021 Aug 20.

  PMID: 34461584 DERIVED

• Kakwangire P, Moss C, Matovu N, Atukunda P, Westerberg AC, Iversen PO, Muhoozi G. The association between dietary diversity and development among children under 24 months in rural Uganda: analysis of a cluster-randomised maternal education trial. Public Health Nutr. 2021 Sep;24(13):4286-4296. doi: 10.1017/S136898002100077X. Epub 2021 Mar 12.

  PMID: 33706831 DERIVED

• Atukunda P, Muhoozi GK, Diep LM, Berg JP, Westerberg AC, Iversen PO. The association of urine markers of iodine intake with development and growth among children in rural Uganda: a secondary analysis of a randomised education trial. Public Health Nutr. 2021 Aug;24(12):3730-3739. doi: 10.1017/S1368980020001603. Epub 2020 Jul 13.

  PMID: 32654677 DERIVED

• Atukunda P, Muhoozi GKM, van den Broek TJ, Kort R, Diep LM, Kaaya AN, Iversen PO, Westerberg AC. Child development, growth and microbiota: follow-up of a randomized education trial in Uganda. J Glob Health. 2019 Jun;9(1):010431. doi: 10.7189/jogh.09.010431.

  PMID: 31131103 DERIVED

• Muhoozi GKM, Atukunda P, Diep LM, Mwadime R, Kaaya AN, Skaare AB, Willumsen T, Westerberg AC, Iversen PO. Nutrition, hygiene, and stimulation education to improve growth, cognitive, language, and motor development among infants in Uganda: A cluster-randomized trial. Matern Child Nutr. 2018 Apr;14(2):e12527. doi: 10.1111/mcn.12527. Epub 2017 Sep 19.

  PMID: 28925580 DERIVED

MeSH Terms

Conditions

Infant Nutrition Disorders

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 21, 2014
• First Posted: March 27, 2014
• Study Start: March 1, 2014
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 20, 2024

Record last verified: 2024-11

Locations

UG (1)