A Novel Drug for Borderline Personality Disorder

NCT02097706 | Recruiting Phase 2 DMC

• 1 other identifier: 204-14
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Borderline Personality Disorder (BPD) is one of the most prevalent psychiatric disorders with high morbidity and mortality. It affects the lives of millions worldwide and is often highly incapacitating, leading to significant psychosocial dysfunction. Moreover, nearly all patients have experienced suicidal ideation and about 10% actually commit suicide, a rate almost 50 times higher than in the general population. Mostly young women are at greater risk for the disorder and are three times more likely to be diagnosed with BPD than men. BPD aetiology is complex and could be explained by both biological and environmental factors. Among the environmental factors, sexual or physical abuse, parental divorce, loss or illnesses are identified as the most common ones. These factors can induce dysfunctional behaviours, which might cause emotional dysregulation, high impulsivity and frequent self- injurious behaviour. However, there are no pharmacologic interventions that are known to be specifically effective to treat BPD. Therapeutic options for this devastating disorder is still far from adequate for treating acute illness episodes, relapses, and recurrences and in restoring premorbid functioning. In addition, some patients are unable to tolerate existing therapies for BPD, which leads to either frequent changes in medications or to non-adherence. Therefore there is an urgent need for the development of more rapidly effective treatments for BPD. A growing body of evidence suggests that glutamatergic neurotransmission, in particular N-methyl-D-aspartate (NMDA) subtype may play a role in the pathophysiology of multiple psychiatric disorders. This has led to various clinical trials with glutamate modulating drugs. The trial drug is an uncompetitive NMDA receptor antagonist approved for Alzheimer's disease is increasingly being studied in a variety of non-dementia psychiatric disorders. Results from these studies have proved that the trial drug was safe and well tolerated and has the potential for use in the treatment of psychiatric disorders. To date, there are no published data on the use of trial drug in the treatment for BPD. Therefore, the investigators intend to study the efficacy of this novel drug as an addition to ongoing therapy with atypical antipsychotics in patients with Borderline Personality Disorder. This study will recruit 150 BPD patients. The patients will be randomly allocated to receive either the study medication (20mg/ day) or placebo via oral administration for twelve weeks. To observe the efficacy of the trial treatment, all participants will be assessed at various time intervals for different borderline and cognitive symptoms.

Conditions

Borderline Personality Disorder

Keywords

Boderline Personality Disorder; Mental Illness; Cognition

Outcome Measures

Primary Outcomes (1)

• The Zanarini Rating Scale for Borderline Personality Disorder

  The Zanarini Rating Scale is a nine-item, validated, clinician-based diagnostic interview. It assesses the severity of DSM-IV-based Borderline personality disorder symptoms. This scale also measures meaningful changes in symptoms over time.

  Weeks 0, 2, 4, 6, 8, 10, 12

Secondary Outcomes (3)

• Borderline Evaluation of Severity over Time (BEST)

  Weeks 0,2,4,6,8,10,12

• BPDSI

  Baseline and Week 12

• Cogstate (cognitive assessment)

  Baseline and Week 12

Study Arms (2)

NMDA receptor antagonist

ACTIVE COMPARATOR

20mg/daily for 12 weeks (84 days)

Drug: NMDA receptor antagonist (active drug)

Placebo tablet

PLACEBO COMPARATOR

1 capsule/daily for 12 weeks (84 days)

Other: Lactose packed capsule (inert/inactive arm)

Interventions

NMDA receptor antagonist (active drug) DRUG

NMDA receptor antagonist

Lactose packed capsule (inert/inactive arm) OTHER

Placebo tablet

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants will be eligible to proceed in the study if they meet all of the following criteria (as determined in the screening session):
• Men and women aged between 18-65 years of age
• A current diagnosis of BPD, or a score ≥ 8 on Diagnostic Interview for Borderline patients, or a score ≥ 15 on Zanarini Rating Scale for Borderline Personality Disorder
• Proficient in reading and writing English

You may not qualify if:

• Potential participants who meet the criteria for any of the following will be excluded from participating in the study:
• Clinical evidence of acute delirium or severe head injury
• Epilepsy or other current seizure disorder, history of seizures or convulsions (not including febrile convulsions), or presence of predisposing factors for epilepsy.
• Clinically significant hepatic or renal impairment, haematological, or cardiovascular disease.
• Concomitant use of NMDA antagonists (amantadine, ketamine, dextromethorphan), L-dopa, dopamine agonists or anticholinergics.
• Lifetime diagnosis of schizophrenia, schizoaffective disorder, substance-induced psychotic disorder or bipolar I disorder (DSM-V).
• Risk of suicide such that inpatient admission is required, as determined by PI (psychiatrist) on the basis of clinical assessment and baseline BPDSI-IV and/or ZAN-BPD suicide subscale scores.
• Taking more than 4 psychotropic medications.
• Planned changes to psychotropic medication or psychotherapy regime.
• Substance abuse or dependence requiring intervention or rehabilitation in last 3 months.
• Pregnant or breastfeeding; if of child-bearing age, not using appropriate contraceptive precaution.

Sponsors & Collaborators

• The Alfred: lead

Study Sites (1)

Monash Alfred Psychiatry Research Centre

Melbourne, Victoria, 3004, Australia

RECRUITING

Related Publications (2)

• Stoffers-Winterling JM, Storebo OJ, Pereira Ribeiro J, Kongerslev MT, Vollm BA, Mattivi JT, Faltinsen E, Todorovac A, Jorgensen MS, Callesen HE, Sales CP, Schaug JP, Simonsen E, Lieb K. Pharmacological interventions for people with borderline personality disorder. Cochrane Database Syst Rev. 2022 Nov 14;11(11):CD012956. doi: 10.1002/14651858.CD012956.pub2.

  PMID: 36375174 DERIVED

• Kulkarni J, Thomas N, Hudaib AR, Gavrilidis E, Grigg J, Tan R, Cheng J, Arnold A, Gurvich C. Effect of the Glutamate NMDA Receptor Antagonist Memantine as Adjunctive Treatment in Borderline Personality Disorder: An Exploratory, Randomised, Double-Blind, Placebo-Controlled Trial. CNS Drugs. 2018 Feb;32(2):179-187. doi: 10.1007/s40263-018-0506-8.

  PMID: 29549516 DERIVED

MeSH Terms

Conditions

Borderline Personality Disorder; Mental Disorders

Condition Hierarchy (Ancestors)

Personality Disorders

Study Officials

• Jayashri Kulkarni AM, MBBS,MPM,FRANZCP,PhD

  Bayside Health, Alfred Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jayashri Kulkarni AM, MBBS,MPM,FRANZCP,PhD

CONTACT

+61 3 90766924; j.kulkarni@alfred.org.au

Anthony deCastella, DipAppSci,BA,MA

CONTACT

+61 3 90766564; a.decastella@alfred.org.au

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 25, 2014
• First Posted: March 27, 2014
• Study Start: January 1, 2015
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: August 15, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)