NCT02092974|CompletedPhase 1
Mechanism of tDCS-induced Learning Enhancement - the Role of Serotonin
LESO
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LESO
Sponsor study identifier
interventional
40
1 country
1
Study Start
April 2014
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2014
Actual (reported)Study Completion
December 2014
Actual (reported)The aim of this study is to assess whether the application of a selective serotonin reuptake inhibitor (SSRI) enhances and prolongs the learning enhancement achieved by anodal transcranial direct current stimulation (atDCS). For this, young and older healthy subjects will be tested with a well established learning paradigm. Results of this study may help to support the application of atDCS also in patients, e.g. with dementia or mild cognitive impairment.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2014
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 19, 2014
Actual (reported)March 20, 2014
Actual (reported)April 2014
Date type not reportedThis date has not been verified as actual or estimated.
December 2014
Actual (reported)December 2014
Actual (reported)Recall score after learning under tDC stimulation + SSRI compared to learning under tDC stimulation + placebo.
Recall score immediately after learning phase (=training of visual-spatial abilities) under tDC stimulation + SSRI application compared to learning under tDC stimulation + placebo.
immediately after end of learning phase (approx. 1 hour)
prolongation of the atDCS induced learning enhancement by SSRI
1 week
Increase of learning enhancement by atDCS + placebo or sham-tDCS + SSRI vs. sham-tDCS + placebo
immediately after learning phase (approx. 1 hour)
prolongation of learning enhancement by atDCS + placebo or sham-tDCS + SSRI vs. sham-tDCS + placebo
1 week
genotyping of learning related polymorphisms
once
Charite Universitätsmedizin Berlin
Berlin, 10117, Germany
Prehn K, Stengl H, Grittner U, Kosiolek R, Olschlager A, Weidemann A, Floel A. Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults. Neuropsychopharmacology. 2017 Jan;42(2):551-561. doi: 10.1038/npp.2016.170. Epub 2016 Aug 24.
Agnes Flöel, Prof. Dr.
Charite University, Berlin, Germany
40 participants (actual enrollment reported by the registry).
First Submitted
March 19, 2014
First Posted
March 20, 2014
Study Start
April 2014
Date type not reportedThis date has not been verified as actual or estimated.
Pharmacokinetic Drug-drug Interaction Study Between RaltEgravir and CITALopram in Healthy Subjects (RECITAL).
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
December 2014
Actual (reported)Study Completion
December 2014
Actual (reported)Last Updated
May 12, 2021
Record last verified: 2021-05
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Source: ClinicalTrials.gov.
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