S. Aureus Colonization in Atopic Dermatitis

NCT02091037 | Completed DMC

• 1 other identifier: AAAI5956
• Study Type: observational
• Target: 114
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis. The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.

Conditions

Atopic Dermatitis

Keywords

Atopic dermatitis; Bacterial colonization

Outcome Measures

Primary Outcomes (1)

• Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis

  Up to 3 years

Secondary Outcomes (1)

• Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis

  Up to 20 years

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be recruited from the pediatric dermatology faculty practices and resident clinics at CUMC as well as from the units of the Morgan Stanley Children's Hospital of New York. As per CUMC policy, the investigators will not directly approach potential subjects until the subject's physician has ascertained and documented that their patient is willing to discuss the research with the investigators.

You may qualify if:

• subjects with a diagnosis of atopic dermatitis seen by the Columbia University Medical Center department of dermatology
• subjects ages 0 to 18 years

You may not qualify if:

• those patients in which a definitive diagnosis of AD cannot be made
• subjects over the age of 18 years old
• subjects with evidence of acute systemic illness
• subjects currently taking systemic antibiotics
• subjects with viral or fungal skin infection
• any individual who declines participation

Sponsors & Collaborators

• Columbia University: lead
• Society for Pediatric Dermatology: collaborator

Study Sites (1)

Columbia University Medical Center / Department of Dermatology

New York, New York, 10032, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Skin culture specimens are retained

MeSH Terms

Conditions

Dermatitis, Atopic

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Christine T Lauren, MD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 17, 2014
• First Posted: March 19, 2014
• Study Start: December 1, 2011
• Primary Completion: December 1, 2016
• Study Completion: January 11, 2017
• Last Updated: January 10, 2022

Record last verified: 2022-01

Locations

US (1)