Hair Cortisol and the Risk of Stroke
1 other identifier
observational
50
1 country
1
Brief Summary
The purpose of this study is to prospectively examine the relation between ischemic stroke and hair cortisol concentration. The investigators hypothesize that patients with ischemic stroke have higher levels of hair cortisol compared to controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2014
CompletedFirst Submitted
Initial submission to the registry
March 12, 2014
CompletedFirst Posted
Study publicly available on registry
March 18, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2016
CompletedMarch 23, 2016
January 1, 2015
2 years
March 12, 2014
March 22, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Concentration of hair cortisol
Hospital stay, on average - 24 hours from admission to hospital
Study Arms (2)
Ischemic stroke
Sudden onset of focal neurologic deficit lasting more than 24 hours, with cerebral hemorrhage ruled out by brain CT, in the absence of obvious causes of embolic stroke.
Control
Patients admitted to an internal medicine department for indications other than stroke or acute myocardial ischemia.
Eligibility Criteria
Cases - Consenting patients admitted to internal medicine wards with acute ischemic (non cardioembolic) stroke. Controls - Consenting patients admitted to internal medicine wards due to indications other than stoke or acute myocardial infarction.
You may qualify if:
- Male patients
- Age of 18 years or older.
You may not qualify if:
- Female sex.
- Patients for whom a hair sample of at least 3cm from vertex posterior cannot be obtained.
- Hemorrhagic stroke.
- Documented atrial fibrillation or flutter during admission or at any time in the past.
- Use of inhaled, systemic or topical corticosteroids at study initiation, or during the previous 12 months.
- Disorders associated with disruption of HPA axis (Cushing syndrome, Addison syndrome).
- Bleaching or use of artificial hair color.
- Inability to sign informed consent.
- Morbid obesity (BMI \> 35).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Meir Medical Center
Kfar Saba, Israel
Related Publications (1)
Stalder T, Kirschbaum C. Analysis of cortisol in hair--state of the art and future directions. Brain Behav Immun. 2012 Oct;26(7):1019-29. doi: 10.1016/j.bbi.2012.02.002. Epub 2012 Feb 15.
PMID: 22366690BACKGROUND
Biospecimen
Hair
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eilon Krashin, MD
Meir Medical Center
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 12, 2014
First Posted
March 18, 2014
Study Start
March 1, 2014
Primary Completion
March 1, 2016
Study Completion
March 1, 2016
Last Updated
March 23, 2016
Record last verified: 2015-01