Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal
1 other identifier
observational
248
1 country
1
Brief Summary
Candidemia has emerged as an important cause of hospital-associated blood-stream infection in children. The purpose of this study was to identify differences in distribution of candida species, risk factors, treatment, and clinical outcome of candidemia in children. This study in children ≤18 years with blood culture proven candidemia identified between 2004 and 2012. Analyses included the determination of causative candida species, resistance to antifungals and clinical outcome, as well as the identification of potential risk factors associated with candidemia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2004
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
March 10, 2014
CompletedFirst Posted
Study publicly available on registry
March 17, 2014
CompletedMarch 17, 2014
March 1, 2014
8.9 years
March 10, 2014
March 14, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Risk factors of candidemia
The presence or absence of potential risk factors for candidemia such as an indwelling central venous catheter (CVC), use of antibiotics (administered for \>72 hours), use of antifungals (administered for \>24 hours), immunosuppressants, total parenteral nutrition (TPN), admission to the intensive care unit (ICU), mechanical ventilation, neutropenia, hypoalbuminemia and hypophosphatemia.
up to 3 months
Secondary Outcomes (1)
Prognosis according to candida species
up to 3 months
Study Arms (1)
Candidemia
Candidemia is defined as the presence of growth of any candida species in at least one blood culture obtained by either peripheral venipuncture or through an indwelling central venous catheter.
Eligibility Criteria
Children diagnosed with candidemia were included in our hospital between Jan 2004 and Dec 2012.
You may qualify if:
- Presence of growth of any candida species in at least one blood culture
You may not qualify if:
- Febrile neutropenic patients who were using empirical antifungal agents
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hacettepe University Faculty of Medicine
Ankara, 06100, Turkey (Türkiye)
Related Publications (1)
Karadag-Oncel E, Kara A, Ozsurekci Y, Arikan-Akdagli S, Cengiz AB, Ceyhan M, Gur D, Celik M, Ozkaya-Parlakay A. Candidaemia in a paediatric centre and importance of central venous catheter removal. Mycoses. 2015 Mar;58(3):140-8. doi: 10.1111/myc.12288. Epub 2015 Feb 10.
PMID: 25678411DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Hacettepe University Department of Pediatric Infectious Diseases
Study Record Dates
First Submitted
March 10, 2014
First Posted
March 17, 2014
Study Start
January 1, 2004
Primary Completion
December 1, 2012
Study Completion
June 1, 2013
Last Updated
March 17, 2014
Record last verified: 2014-03