Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients
PtcO2-FR
1 other identifier
observational
19
1 country
1
Brief Summary
Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO2) in the critically ill patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2011
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 7, 2014
CompletedFirst Posted
Study publicly available on registry
March 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2014
CompletedMay 27, 2015
May 1, 2015
2.6 years
March 7, 2014
May 26, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cardiac Output
Noninvasive bioreactance CO monitoring was obtained using the NICOM system (Cheetah Medical, Portland, OR) with four double-electrode stickers placed on the chest wall.
30min
Study Arms (2)
Resp
Fluid responsiveness is defined as a change of stroke volume stroke volume ≥ 10% after 250 ml rapid saline infusion in 10 minutes.
Nonresp
Fluid responsiveness is defined as a change of stroke volume stroke volume \< 10% after 250 ml rapid saline infusion in 10 minutes.
Eligibility Criteria
Patients for whom the attending physician decided to perform a fluid challenge or presence of at least one clinical sign of inadequate tissue perfusion in the absence of contraindication for fluid infusion for less than 24 hours were eligible to participate in the study.
You may qualify if:
- clinical signs of inadequate tissue perfusion defined as systolic blood pressure \< 90 mm Hg or a decrease \> 40 mmHg in previously hypertensive patients or the need for vasopressive drugs (dopamine \> 5 ug/kg/min or norepinephrine); urine output \< 0.5 ml/kg/hr for 2 hrs; tachycardia; presence of skin mottling.
You may not qualify if:
- pregnancy, age of less than 18 years, contraindication to passive leg raising test, cardiac arrhythmias, cardiogenic pulmonary edema, the presence of abdominal compartment syndrome and refusal to participate in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210000, China
Related Publications (1)
Xu J, Peng X, Pan C, Cai S, Zhang X, Xue M, Yang Y, Qiu H. Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study. Ann Intensive Care. 2017 Dec;7(1):56. doi: 10.1186/s13613-017-0279-0. Epub 2017 May 23.
PMID: 28536944DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Zhongda Hospital
Study Record Dates
First Submitted
March 7, 2014
First Posted
March 11, 2014
Study Start
September 1, 2011
Primary Completion
April 1, 2014
Study Completion
May 1, 2014
Last Updated
May 27, 2015
Record last verified: 2015-05