C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease
1 other identifier
observational
500
1 country
1
Brief Summary
Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2012
CompletedFirst Submitted
Initial submission to the registry
March 7, 2014
CompletedFirst Posted
Study publicly available on registry
March 11, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedSeptember 21, 2016
September 1, 2016
4.8 years
March 7, 2014
September 19, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD
at enrollment
Secondary Outcomes (1)
The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles
at enrollment
Study Arms (1)
Patients with NAFLD
Eligibility Criteria
The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.
You may qualify if:
- \<age\<80
- apparently healthy subjects
You may not qualify if:
- a history of CVD
- diabetes
- stage 2 hypertension
- malignancy
- severe renal or hepatic disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Korea Universitylead
Study Sites (1)
Korea Univ. Guro Hospital
Seoul, South Korea
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
March 7, 2014
First Posted
March 11, 2014
Study Start
March 1, 2012
Primary Completion
December 1, 2016
Last Updated
September 21, 2016
Record last verified: 2016-09