NCT02083146

Brief Summary

Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
362

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2011

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2011

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

March 7, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 11, 2014

Completed
1.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2016

Completed
Last Updated

March 20, 2018

Status Verified

March 1, 2018

Enrollment Period

1.8 years

First QC Date

March 7, 2014

Last Update Submit

March 17, 2018

Conditions

Coronary Artery Disease (CAD)

Outcome Measures

Primary Outcomes (1)

  • serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD

    compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group

    at enrollment

Secondary Outcomes (1)

  • The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles

    at enrollment

Study Arms (1)

Patients with CAD

Acute coronary syndromoe (ACS) patients who were admitted to the coronary care unit.

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The subjects with stable angina or a history of acute coronary syndrome who visited for a department of cardiology in Korea Univ. Guro hospital were enrolled using predefined inclusion and exclusion criteria.

You may qualify if:

  • \<age\<80
  • History of stable angina, unstable angina, or acute myocardial infarction

You may not qualify if:

  • a history of diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Korea Univ. Guro Hospital

Seoul, South Korea

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Newly-developed ELISA was used for measurement of CTRP.

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Kyung Mook Choi, M.D.

    medica7@gmail.com

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

March 7, 2014

First Posted

March 11, 2014

Study Start

March 1, 2011

Primary Completion

December 1, 2012

Study Completion

February 1, 2016

Last Updated

March 20, 2018

Record last verified: 2018-03

Locations

KR(1)