Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
2 other identifiers
interventional
220
1 country
1
Brief Summary
Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Sep 2012
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2013
CompletedFirst Submitted
Initial submission to the registry
January 13, 2014
CompletedFirst Posted
Study publicly available on registry
March 6, 2014
CompletedMarch 6, 2014
March 1, 2014
1 year
January 13, 2014
March 4, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
screening of Cessation of bleeding
screening until 24 hours after placenta disconnection
time duration to stop bleeding in the case of post-cesarean section
24 hours
Study Arms (2)
Oxytocin
EXPERIMENTALA single 100 microgram IV dose of carbetocin after operation
Carbetocin
EXPERIMENTALA standard 30 international units (IU) IV infusion of oxytocin during two hours
Interventions
Carbetocin with single 100 microg IV dosage was used in this investigation
Oxytocin with 30 international units (IU) IV infusion was used in this investigation
Eligibility Criteria
You may qualify if:
- At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin
You may not qualify if:
- Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Infertility and Reproductive Health Research Center
Tehran, Tehran Province, 1985717443, Iran
Related Publications (1)
Taheripanah R, Shoman A, Karimzadeh MA, Zamaniyan M, Malih N. Efficacy of oxytocin versus carbetocin in prevention of postpartum hemorrhage after cesarean section under general anesthesia: a prospective randomized clinical trial. J Matern Fetal Neonatal Med. 2018 Nov;31(21):2807-2812. doi: 10.1080/14767058.2017.1355907. Epub 2017 Jul 25.
PMID: 28707488DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robabeh Taheripanah, MD-Gyn.
Infertility and Reproductive health Research center, Imam Hossien hospital, Shahid Beheshti Medical university, Tehran, Iran
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- SCREENING
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associated prof. Obstetrics & Gynecology
Study Record Dates
First Submitted
January 13, 2014
First Posted
March 6, 2014
Study Start
September 1, 2012
Primary Completion
September 1, 2013
Study Completion
September 1, 2013
Last Updated
March 6, 2014
Record last verified: 2014-03