Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults
1 other identifier
interventional
24
1 country
1
Brief Summary
Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2013
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedFirst Submitted
Initial submission to the registry
February 11, 2014
CompletedFirst Posted
Study publicly available on registry
March 4, 2014
CompletedMarch 4, 2014
March 1, 2014
6 months
February 11, 2014
March 3, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Motor evoked potential
measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.
Baseline
Intracortical inhibition, ICI
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Baseline,2 hours, 2.5 hours,and 3 hours
intracortical facilitation, ICF
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Baseline,Baseline,2 hours, 2.5 hours,and 3 hours
Study Arms (3)
120Hz alternating current stimulation group
ACTIVE COMPARATOR5Hz alternating current stimulation group
ACTIVE COMPARATORsham alternating current stimulation group
SHAM COMPARATORInterventions
Then participants will receive stimulation for 20 minutes.
Eligibility Criteria
You may qualify if:
- Healthy adults
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chang Gung University
Taoyuan District, 333, Taiwan
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 11, 2014
First Posted
March 4, 2014
Study Start
January 1, 2013
Primary Completion
July 1, 2013
Study Completion
July 1, 2013
Last Updated
March 4, 2014
Record last verified: 2014-03